Motif ID: Nr6a1

Z-value: 0.491


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_38926454-0.172.9e-01Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 63 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_172472512 2.097 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr1_-_79858627 1.939 ENSMUST00000027467.4
 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr14_+_12189943 1.872 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr13_-_24761440 1.859 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr12_+_3807017 1.842 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A

chr19_+_46707443 1.705 ENSMUST00000003655.7
 As3mt
arsenic (+3 oxidation state) methyltransferase
chr7_-_66427469 1.652 ENSMUST00000015278.7
 Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr12_+_3807076 1.613 ENSMUST00000174817.1
 Dnmt3a
DNA methyltransferase 3A
chr15_-_98165613 1.514 ENSMUST00000143400.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr14_+_58072686 1.502 ENSMUST00000022545.7
 Fgf9
fibroblast growth factor 9
chr11_-_69822144 1.422 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr6_+_83349446 1.368 ENSMUST00000136501.1
 Bola3
bolA-like 3 (E. coli)
chr17_+_72918298 1.315 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr9_-_96437434 1.302 ENSMUST00000070500.2
 BC043934
cDNA sequence BC043934
chr7_+_30314810 1.176 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr1_+_131970589 1.156 ENSMUST00000027695.6
 Slc45a3
solute carrier family 45, member 3
chr10_+_128083273 1.105 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr6_+_42245907 1.031 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr12_-_115790884 1.006 ENSMUST00000081809.5
 Ighv1-73
immunoglobulin heavy variable 1-73
chr9_+_50603892 0.994 ENSMUST00000044051.4
 Timm8b
translocase of inner mitochondrial membrane 8B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.5 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.5 1.9 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 1.9 GO:1901998 toxin transport(GO:1901998)
0.0 1.9 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.4 1.8 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.6 1.7 GO:0060166 olfactory pit development(GO:0060166)
0.1 1.7 GO:0009404 toxin metabolic process(GO:0009404)
0.1 1.5 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 1.4 GO:0030317 sperm motility(GO:0030317)
0.3 1.3 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.4 1.2 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 1.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 1.2 GO:0051225 spindle assembly(GO:0051225)
0.3 1.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 1.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.9 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 0.8 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0001741 XY body(GO:0001741)
0.2 1.9 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.1 1.2 GO:0044453 nuclear membrane part(GO:0044453)
0.1 1.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 1.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.9 GO:0070652 HAUS complex(GO:0070652)
0.0 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.8 GO:0030286 dynein complex(GO:0030286)
0.2 0.7 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.7 GO:0033391 eukaryotic translation initiation factor 4F complex(GO:0016281) chromatoid body(GO:0033391)
0.1 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.4 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.4 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 1.7 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 1.7 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.4 1.2 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 1.1 GO:0043532 angiostatin binding(GO:0043532)
0.1 1.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.3 1.0 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) serine binding(GO:0070905)
0.1 1.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.0 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 0.7 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.7 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.5 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.0 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.5 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 1.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 1.5 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.7 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_KINESINS Genes involved in Kinesins