Motif ID: Nrf1

Z-value: 2.685


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30048062_30048078-0.153.5e-01Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_79682304 7.072 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr15_+_88751649 6.971 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr10_+_79682169 4.963 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr2_+_157560078 4.508 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
 Nnat







neuronatin







chr11_+_73177236 4.405 ENSMUST00000108477.1
 Tax1bp3
Tax1 (human T cell leukemia virus type I) binding protein 3
chr13_-_53286052 4.079 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr12_+_16810940 4.007 ENSMUST00000020908.7
 E2f6
E2F transcription factor 6
chr11_+_73177083 3.932 ENSMUST00000040687.5
 Tax1bp3
Tax1 (human T cell leukemia virus type I) binding protein 3
chr11_+_78094660 3.906 ENSMUST00000073705.5
 Fam222b
family with sequence similarity 222, member B
chr1_-_138856819 3.709 ENSMUST00000112025.1
 2310009B15Rik
RIKEN cDNA 2310009B15 gene
chr14_+_59625281 3.683 ENSMUST00000053949.5
 Shisa2
shisa homolog 2 (Xenopus laevis)
chr7_-_137314394 3.662 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr15_-_72546279 3.653 ENSMUST00000044624.6
 Kcnk9
potassium channel, subfamily K, member 9
chr4_+_59581645 3.637 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr11_+_78094682 3.620 ENSMUST00000100782.3
 Fam222b
family with sequence similarity 222, member B
chr4_+_59581563 3.561 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr16_+_90727490 3.554 ENSMUST00000181232.1
 Gm17518
predicted gene, 17518
chr11_+_86544982 3.503 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
 Tubd1



tubulin, delta 1



chr5_-_106458440 3.499 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr5_+_36484578 3.420 ENSMUST00000060100.1
 Ccdc96
coiled-coil domain containing 96

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 583 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 11.8 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 10.4 GO:0006457 protein folding(GO:0006457)
0.2 8.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6 8.3 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.2 6.8 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 6.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.2 6.1 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
1.2 6.0 GO:0007403 glial cell fate determination(GO:0007403)
0.1 5.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.5 5.8 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.3 5.6 GO:0043968 histone H2A acetylation(GO:0043968)
1.1 5.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 5.1 GO:0042168 heme metabolic process(GO:0042168)
0.2 4.9 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 4.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.6 4.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.4 4.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.6 4.2 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.1 4.2 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.4 4.1 GO:1905216 positive regulation of RNA binding(GO:1905216)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 278 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 24.1 GO:0005739 mitochondrion(GO:0005739)
0.1 14.8 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 11.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 7.8 GO:0060076 excitatory synapse(GO:0060076)
0.3 7.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 7.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 6.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 6.3 GO:0090544 BAF-type complex(GO:0090544)
0.1 5.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.5 5.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
1.9 5.7 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 5.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.6 5.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 5.2 GO:0045120 pronucleus(GO:0045120)
0.1 5.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 5.2 GO:0005643 nuclear pore(GO:0005643)
0.0 5.2 GO:0043296 apical junction complex(GO:0043296)
0.1 5.0 GO:0031965 nuclear membrane(GO:0031965)
0.6 4.9 GO:0033269 internode region of axon(GO:0033269)
0.7 4.7 GO:0005726 perichromatin fibrils(GO:0005726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 357 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.8 12.9 GO:0030957 Tat protein binding(GO:0030957)
0.4 12.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 11.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 9.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 8.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 7.4 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.2 6.8 GO:0050699 WW domain binding(GO:0050699)
0.1 6.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.6 6.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 5.9 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.1 5.8 GO:0051082 unfolded protein binding(GO:0051082)
0.3 5.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 5.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 5.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 5.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 4.8 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.2 4.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 4.6 GO:0003684 damaged DNA binding(GO:0003684)
0.3 4.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 6.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 6.4 PID_PLK1_PATHWAY PLK1 signaling events
0.1 5.5 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 5.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 5.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 4.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 4.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.3 4.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 4.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 4.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 3.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 3.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 2.4 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.4 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 2.4 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 11.8 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.2 10.9 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.3 10.0 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 9.4 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 8.5 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 8.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 7.1 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 6.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 6.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 6.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 6.2 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.2 5.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 4.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 4.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 4.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 4.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 4.1 REACTOME_INFLUENZA_LIFE_CYCLE Genes involved in Influenza Life Cycle
0.3 4.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 3.9 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus