Motif ID: Obox6_Obox5

Z-value: 0.780

Transcription factors associated with Obox6_Obox5:

Gene SymbolEntrez IDGene Name
Obox5 ENSMUSG00000074366.3 Obox5
Obox6 ENSMUSG00000041583.7 Obox6



Activity profile for motif Obox6_Obox5.

activity profile for motif Obox6_Obox5


Sorted Z-values histogram for motif Obox6_Obox5

Sorted Z-values for motif Obox6_Obox5



Network of associatons between targets according to the STRING database.



First level regulatory network of Obox6_Obox5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_1010543 11.996 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr14_-_20181773 5.930 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr7_-_4752972 4.009 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr7_+_16781341 3.317 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr9_-_37433138 3.052 ENSMUST00000115038.1
 Robo3
roundabout homolog 3 (Drosophila)
chr17_-_25797032 3.004 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr10_+_94198955 2.918 ENSMUST00000020209.9
ENSMUST00000179990.1
 Ndufa12

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12

chr3_-_73708399 2.900 ENSMUST00000029367.5
 Bche
butyrylcholinesterase
chr9_+_108479849 2.880 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr19_+_53140430 2.720 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr9_+_51621425 2.711 ENSMUST00000089534.4
 Gm7293
predicted gene 7293
chr2_+_164562579 2.629 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr7_-_103843154 2.583 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr6_-_23248264 2.557 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr14_-_87141206 2.556 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr8_+_94179089 2.485 ENSMUST00000034215.6
 Mt1
metallothionein 1
chrX_+_52791179 2.461 ENSMUST00000101588.1
 Ccdc160
coiled-coil domain containing 160
chr16_+_90831113 2.415 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr3_-_25212720 2.410 ENSMUST00000091289.3
 Gm10259
predicted pseudogene 10259
chr9_-_8004585 2.276 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.4 GO:0006413 translational initiation(GO:0006413)
0.6 5.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 3.4 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.8 3.3 GO:0015825 L-serine transport(GO:0015825)
0.6 3.1 GO:0061642 chemoattraction of axon(GO:0061642)
1.0 2.9 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.6 2.9 GO:0014016 neuroblast differentiation(GO:0014016) response to folic acid(GO:0051593)
0.6 2.9 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.2 2.9 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.5 2.7 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 2.7 GO:0042493 response to drug(GO:0042493)
0.9 2.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 2.6 GO:0015671 oxygen transport(GO:0015671)
0.1 2.6 GO:0021591 ventricular system development(GO:0021591)
0.0 2.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.4 2.5 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
0.0 2.5 GO:0006457 protein folding(GO:0006457)
0.4 2.3 GO:0060242 contact inhibition(GO:0060242)
0.7 2.2 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 2.0 GO:0060134 prepulse inhibition(GO:0060134)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.0 GO:0030061 mitochondrial crista(GO:0030061)
0.1 3.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.5 2.9 GO:0043256 laminin complex(GO:0043256)
0.2 2.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 2.6 GO:0005833 hemoglobin complex(GO:0005833)
0.0 2.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.8 2.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 2.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 2.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 2.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 2.1 GO:0016363 nuclear matrix(GO:0016363)
0.6 1.9 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 1.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 1.8 GO:0005663 DNA replication factor C complex(GO:0005663)
0.2 1.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.6 GO:0097542 ciliary tip(GO:0097542)
0.3 1.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 1.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 6.1 GO:0042393 histone binding(GO:0042393)
0.5 5.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 3.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.7 GO:0005507 copper ion binding(GO:0005507)
0.2 3.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 3.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 3.0 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 2.9 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.7 2.9 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.0 2.9 GO:0005178 integrin binding(GO:0005178)
0.0 2.9 GO:0008201 heparin binding(GO:0008201)
0.0 2.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.6 2.6 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.5 2.6 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.8 2.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.5 2.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 2.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 2.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.6 1.9 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 4.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 3.2 PID_FGF_PATHWAY FGF signaling pathway
0.4 2.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.8 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.6 SIG_CHEMOTAXIS Genes related to chemotaxis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 4.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 3.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 3.2 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 2.8 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 2.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 2.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 2.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 2.2 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 2.1 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.9 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.1 1.7 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 1.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 0.9 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 0.9 REACTOME_POL_SWITCHING Genes involved in Polymerase switching