Motif ID: Olig2_Olig3

Z-value: 0.588

Transcription factors associated with Olig2_Olig3:

Gene SymbolEntrez IDGene Name
Olig2 ENSMUSG00000039830.8 Olig2
Olig3 ENSMUSG00000045591.5 Olig3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Olig2mm10_v2_chr16_+_91225550_91225579-0.095.9e-01Click!
Olig3mm10_v2_chr10_+_19356558_193565650.057.8e-01Click!


Activity profile for motif Olig2_Olig3.

activity profile for motif Olig2_Olig3


Sorted Z-values histogram for motif Olig2_Olig3

Sorted Z-values for motif Olig2_Olig3



Network of associatons between targets according to the STRING database.



First level regulatory network of Olig2_Olig3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92164666 6.041 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr1_-_186117251 4.741 ENSMUST00000045388.7
 Lyplal1
lysophospholipase-like 1
chr16_-_44558864 3.549 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr16_-_44558879 3.424 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr19_-_53589067 3.316 ENSMUST00000095978.3
 Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr3_-_154330543 3.222 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr3_+_125404072 3.161 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_125404292 3.085 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr2_-_105399286 2.951 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr19_+_20601958 2.708 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr17_-_62606679 2.681 ENSMUST00000163332.1
 Efna5
ephrin A5
chr11_-_69920892 2.560 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr11_+_32276400 2.544 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr1_+_110099295 2.447 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr9_-_119825456 2.426 ENSMUST00000070617.7
 Scn11a
sodium channel, voltage-gated, type XI, alpha
chr8_+_31089471 2.208 ENSMUST00000036631.7
ENSMUST00000170204.1
 Dusp26

dual specificity phosphatase 26 (putative)

chr9_+_76014855 2.026 ENSMUST00000008052.6
ENSMUST00000183425.1
ENSMUST00000183979.1
ENSMUST00000117981.2
 Hmgcll1



3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1



chrX_+_93286499 1.988 ENSMUST00000046565.7
ENSMUST00000113947.2
 Arx

aristaless related homeobox

chr11_-_75796048 1.988 ENSMUST00000021209.7
 Doc2b
double C2, beta
chr10_+_53596936 1.949 ENSMUST00000020004.6
 Asf1a
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.8 4.7 GO:0098734 protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) macromolecule depalmitoylation(GO:0098734)
0.2 3.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.5 3.2 GO:0032796 uropod organization(GO:0032796)
0.5 3.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 3.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 2.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 2.7 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.5 2.5 GO:0015671 oxygen transport(GO:0015671)
0.0 2.3 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.7 2.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.7 2.0 GO:0021759 globus pallidus development(GO:0021759)
0.4 2.0 GO:0046950 cellular ketone body metabolic process(GO:0046950)
0.1 2.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.6 1.9 GO:0002159 desmosome assembly(GO:0002159) adherens junction maintenance(GO:0034334) intermediate filament bundle assembly(GO:0045110) maintenance of organ identity(GO:0048496)
0.1 1.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 1.7 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.3 1.7 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.5 1.6 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.4 1.6 GO:0006545 glycine biosynthetic process(GO:0006545)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 GO:0044295 axonal growth cone(GO:0044295)
0.5 3.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 3.2 GO:0032426 stereocilium tip(GO:0032426)
0.3 3.1 GO:0005642 annulate lamellae(GO:0005642)
0.2 2.8 GO:0030057 desmosome(GO:0030057)
0.2 2.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.3 2.5 GO:0005833 hemoglobin complex(GO:0005833)
0.8 2.4 GO:0044299 C-fiber(GO:0044299)
0.0 2.0 GO:0031201 SNARE complex(GO:0031201)
0.0 2.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.7 GO:0030870 Mre11 complex(GO:0030870)
0.3 1.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.6 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 1.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 1.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 4.7 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.5 3.5 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 3.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 3.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 3.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.5 2.7 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 2.7 GO:0045499 chemorepellent activity(GO:0045499)
0.5 2.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.7 2.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 2.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 2.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 2.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 2.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 1.7 GO:0008494 translation activator activity(GO:0008494)
0.0 1.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 1.6 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 3.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.7 PID_BARD1_PATHWAY BARD1 signaling events
0.1 1.8 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 0.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 PID_ATM_PATHWAY ATM pathway
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 0.7 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 6.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.1 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.7 2.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 2.6 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.1 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 2.0 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 0.9 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines