Motif ID: Onecut1_Cux2

Z-value: 1.248

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.595.1e-05Click!
Cux2mm10_v2_chr5_-_122049822_122049882-0.296.8e-02Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 26.690 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_102010138 14.598 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr12_+_55598917 10.069 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr14_+_68083853 9.879 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr12_+_72441933 8.081 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr1_-_158958367 7.720 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr6_+_4755327 6.555 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr10_-_64090265 6.057 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr12_+_72441852 5.805 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr10_-_64090241 5.315 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr18_-_72351029 4.694 ENSMUST00000114943.3
 Dcc
deleted in colorectal carcinoma
chr18_-_72351009 4.659 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma
chr8_+_58911755 4.518 ENSMUST00000062978.6
 BC030500
cDNA sequence BC030500
chrX_+_134404780 4.023 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr3_+_125404072 3.931 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr9_-_50739365 3.910 ENSMUST00000117093.1
ENSMUST00000121634.1
 Dixdc1

DIX domain containing 1

chrX_+_134404543 3.788 ENSMUST00000113228.1
ENSMUST00000153424.1
 Drp2

dystrophin related protein 2

chr1_+_165302625 3.622 ENSMUST00000111450.1
 Gpr161
G protein-coupled receptor 161
chr10_-_112928974 3.438 ENSMUST00000099276.2
 Atxn7l3b
ataxin 7-like 3B
chr7_+_35802593 3.430 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 26.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 14.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.8 11.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
3.3 9.9 GO:0045110 intermediate filament bundle assembly(GO:0045110)
1.6 9.4 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 6.8 GO:0060349 bone morphogenesis(GO:0060349)
0.1 6.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.3 3.9 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 3.8 GO:0050808 synapse organization(GO:0050808)
0.3 3.6 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
1.1 3.4 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.6 3.4 GO:0003383 apical constriction(GO:0003383)
1.0 3.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.2 3.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 2.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.3 2.3 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.7 2.1 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 2.1 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.1 2.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 1.9 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.9 GO:0045211 postsynaptic membrane(GO:0045211)
3.3 9.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.9 9.4 GO:0032584 growth cone membrane(GO:0032584)
0.0 8.5 GO:0005794 Golgi apparatus(GO:0005794)
0.0 3.9 GO:0043679 axon terminus(GO:0043679)
0.0 3.8 GO:0055037 recycling endosome(GO:0055037)
0.4 3.4 GO:0033269 internode region of axon(GO:0033269)
0.6 2.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 2.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 1.9 GO:0044308 axonal spine(GO:0044308)
0.1 1.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.5 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.4 GO:0072562 blood microparticle(GO:0072562)
0.1 1.2 GO:0042587 glycogen granule(GO:0042587)
0.1 1.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.7 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 14.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 13.3 GO:0008270 zinc ion binding(GO:0008270)
0.1 11.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 10.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.4 9.9 GO:0043274 phospholipase binding(GO:0043274)
1.6 9.4 GO:0005042 netrin receptor activity(GO:0005042)
0.1 7.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.0 7.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 4.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 3.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 3.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 3.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.6 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.5 2.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 2.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 2.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.2 1.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 9.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 6.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.9 9.4 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.5 7.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 7.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 3.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 3.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 1.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 1.4 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling