Motif ID: Osr2_Osr1

Z-value: 0.772

Transcription factors associated with Osr2_Osr1:

Gene SymbolEntrez IDGene Name
Osr1 ENSMUSG00000048387.7 Osr1
Osr2 ENSMUSG00000022330.4 Osr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Osr1mm10_v2_chr12_+_9574437_9574448-0.009.9e-01Click!


Activity profile for motif Osr2_Osr1.

activity profile for motif Osr2_Osr1


Sorted Z-values histogram for motif Osr2_Osr1

Sorted Z-values for motif Osr2_Osr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Osr2_Osr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 177 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_90203980 4.237 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr2_-_80128834 3.555 ENSMUST00000102654.4
ENSMUST00000102655.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr4_+_13743424 3.039 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_-_134254076 2.226 ENSMUST00000060050.5
 Grrp1
glycine/arginine rich protein 1
chr2_+_136892168 1.826 ENSMUST00000099311.2
 Slx4ip
SLX4 interacting protein
chr4_+_135963742 1.803 ENSMUST00000149636.1
ENSMUST00000143304.1
 Gale

galactose-4-epimerase, UDP

chr19_+_48206025 1.603 ENSMUST00000078880.5
 Sorcs3
sortilin-related VPS10 domain containing receptor 3
chr19_+_20601958 1.548 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr15_+_84232030 1.465 ENSMUST00000023072.6
 Parvb
parvin, beta
chr3_-_89322883 1.427 ENSMUST00000029673.5
 Efna3
ephrin A3
chr5_+_107497762 1.411 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr5_+_107497718 1.309 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr6_-_59024470 1.294 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr19_-_16873830 1.284 ENSMUST00000072915.2
 Foxb2
forkhead box B2
chr9_-_16378231 1.283 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr15_-_20666750 1.280 ENSMUST00000052910.4
 Acot10
acyl-CoA thioesterase 10
chr19_+_54045182 1.268 ENSMUST00000036700.5
 Adra2a
adrenergic receptor, alpha 2a
chr7_-_57509995 1.251 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr10_-_109823585 1.246 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr3_-_127225847 1.075 ENSMUST00000182726.1
ENSMUST00000182779.1
 Ank2

ankyrin 2, brain


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.2 3.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.4 2.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.7 2.8 GO:0061623 glycolytic process from galactose(GO:0061623)
0.0 2.0 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.2 1.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 1.6 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.5 1.5 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.4 1.5 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 1.4 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.3 1.3 GO:0035624 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) thermoception(GO:0050955)
0.0 1.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.3 GO:0010842 retina layer formation(GO:0010842)
0.0 1.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.2 1.1 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.2 1.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 1.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 1.1 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.5 1.0 GO:0021557 oculomotor nerve development(GO:0021557)
0.3 1.0 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 3.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.4 GO:0030027 lamellipodium(GO:0030027)
0.1 1.9 GO:0031430 M band(GO:0031430)
0.0 1.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.5 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 1.1 GO:0097447 dendritic tree(GO:0097447)
0.1 1.0 GO:0071437 invadopodium(GO:0071437)
0.2 0.9 GO:1990032 parallel fiber(GO:1990032)
0.0 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.6 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.5 GO:0061617 MICOS complex(GO:0061617)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 4.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.5 3.6 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 2.8 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 1.9 GO:0030507 spectrin binding(GO:0030507)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.3 1.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 1.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.4 1.3 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)
0.1 1.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 1.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 1.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.9 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.3 0.8 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 1.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.3 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 2.8 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 1.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.1 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 1.0 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.4 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism