Motif ID: Otx1

Z-value: 0.457


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.631.2e-05Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 91 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_108479849 3.120 ENSMUST00000065014.4
Lamb2
laminin, beta 2
chr5_-_98566762 2.184 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr10_+_3973086 1.534 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr17_+_35861318 1.371 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr3_+_54481429 1.334 ENSMUST00000091130.3
Gm5641
predicted gene 5641
chr16_-_59632520 1.323 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr7_-_38271310 1.322 ENSMUST00000032585.6
Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr5_-_37336870 1.319 ENSMUST00000031005.4
Evc
Ellis van Creveld gene syndrome
chrX_-_48513518 1.276 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr13_-_21750505 1.269 ENSMUST00000102983.1
Hist1h4k
histone cluster 1, H4k
chr10_-_88605017 1.203 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr5_-_5749317 1.192 ENSMUST00000015796.2
Steap1
six transmembrane epithelial antigen of the prostate 1
chr12_-_46818749 1.098 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr14_-_87141206 1.074 ENSMUST00000022599.7
Diap3
diaphanous homolog 3 (Drosophila)
chr8_-_47675556 1.046 ENSMUST00000125536.1
Ing2
inhibitor of growth family, member 2
chr11_+_78346666 1.045 ENSMUST00000100755.3
Unc119
unc-119 homolog (C. elegans)
chr5_-_37336837 0.991 ENSMUST00000114148.1
Evc
Ellis van Creveld gene syndrome
chr1_+_131910458 0.949 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_-_151980135 0.894 ENSMUST00000062047.5
Fam110a
family with sequence similarity 110, member A
chr7_-_4063195 0.865 ENSMUST00000068865.5
ENSMUST00000086400.6
Lair1

leukocyte-associated Ig-like receptor 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.1 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 2.3 GO:0003416 endochondral bone growth(GO:0003416)
0.1 2.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.3 1.5 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.3 1.3 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 1.3 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.1 1.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 1.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 1.2 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 1.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 1.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.3 0.9 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.3 0.8 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 0.8 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.7 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.7 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.7 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.7 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 0.6 GO:0097503 sialylation(GO:0097503)
0.1 0.6 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.1 GO:0043256 laminin complex(GO:0043256)
0.0 2.3 GO:0036064 ciliary basal body(GO:0036064)
0.1 2.1 GO:0005652 nuclear lamina(GO:0005652)
0.1 2.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 1.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.2 GO:0005859 muscle myosin complex(GO:0005859)
0.2 1.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.0 GO:0051233 spindle midzone(GO:0051233)
0.1 0.9 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.8 GO:0030904 retromer complex(GO:0030904)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.1 0.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 0.6 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.5 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.4 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0005178 integrin binding(GO:0005178)
0.0 2.0 GO:0042393 histone binding(GO:0042393)
0.4 1.5 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.4 1.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.4 1.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.4 1.2 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 1.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 1.0 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.9 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 0.7 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 0.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.5 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.5 GO:0050699 WW domain binding(GO:0050699)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.4 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.3 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.6 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.4 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.4 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC