Motif ID: Pax2
Z-value: 1.021
Transcription factors associated with Pax2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pax2 | ENSMUSG00000004231.9 | Pax2 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 108 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.1 | GO:0008643 | carbohydrate transport(GO:0008643) |
| 1.6 | 6.4 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
| 0.1 | 5.2 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.2 | 3.8 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
| 1.2 | 3.6 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
| 0.7 | 3.6 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.8 | 3.4 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.1 | 3.1 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.1 | 3.0 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
| 0.1 | 3.0 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.6 | 2.9 | GO:0042117 | monocyte activation(GO:0042117) |
| 0.9 | 2.8 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.2 | 2.7 | GO:0060693 | regulation of branching involved in salivary gland morphogenesis(GO:0060693) |
| 0.2 | 2.7 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.0 | 2.7 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 2.7 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.4 | 2.5 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.3 | 2.5 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.8 | 2.4 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.5 | 2.4 | GO:0090273 | regulation of somatostatin secretion(GO:0090273) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 48 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.5 | 4.5 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.2 | 3.6 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 3.5 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.3 | 3.4 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.3 | 2.9 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 2.7 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 2.7 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 2.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 2.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.2 | 2.4 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 2.3 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 2.3 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 1.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 1.6 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 1.6 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 1.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 1.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 1.5 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.5 | 1.4 | GO:0005899 | insulin receptor complex(GO:0005899) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 67 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 15.6 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
| 0.0 | 10.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 7.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 2.1 | 6.4 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 4.0 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 3.8 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.4 | 3.4 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.1 | 3.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.5 | 2.7 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 2.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.6 | 2.5 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.1 | 2.4 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 1.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 1.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 1.7 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.1 | 1.7 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 1.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.7 | GO:0050660 | flavin adenine dinucleotide binding(GO:0050660) |
| 0.1 | 1.6 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
Gene overrepresentation in C2:CP category:
Showing 1 to 12 of 12 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 3.3 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.1 | 1.9 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 1.4 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 1.3 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.1 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.0 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.9 | PID_FAS_PATHWAY | FAS (CD95) signaling pathway |
| 0.1 | 0.7 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.4 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 25 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 3.8 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.2 | 2.9 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 2.5 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.9 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.1 | 1.7 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 1.5 | REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS | Genes involved in Acetylcholine Binding And Downstream Events |
| 0.1 | 1.4 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.1 | 1.4 | REACTOME_SOS_MEDIATED_SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.1 | 1.3 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 1.3 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.0 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 1.0 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.0 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.9 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.5 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.5 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
