Motif ID: Pax4

Z-value: 0.459


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Showing 1 to 20 of 77 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_88978958 2.253 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr9_+_32696005 1.783 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
 Ets1


E26 avian leukemia oncogene 1, 5' domain


chr2_+_73271925 1.605 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr12_-_90738438 1.574 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chrX_+_73192222 1.454 ENSMUST00000101486.4
 Xlr3b
X-linked lymphocyte-regulated 3B
chr8_-_84773381 1.249 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chrX_-_73097017 1.154 ENSMUST00000114524.2
ENSMUST00000074619.5
 Xlr3a

X-linked lymphocyte-regulated 3A

chr15_-_79164477 1.145 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chrX_+_9199865 1.089 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr18_+_58836721 1.034 ENSMUST00000052907.5
 Adamts19
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
chr4_-_88033328 1.031 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_+_136357423 1.018 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chr13_-_23430826 0.969 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene

chr12_+_71048338 0.786 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr13_-_101768154 0.775 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chrX_+_142227923 0.752 ENSMUST00000042329.5
 Nxt2
nuclear transport factor 2-like export factor 2
chrX_+_142228177 0.726 ENSMUST00000112914.1
 Nxt2
nuclear transport factor 2-like export factor 2
chr12_-_98577940 0.644 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr12_-_80112998 0.640 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr11_+_78499087 0.531 ENSMUST00000017488.4
 Vtn
vitronectin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.3 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.4 1.8 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.3 1.6 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.0 1.5 GO:0051028 mRNA transport(GO:0051028)
0.1 1.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 1.1 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.1 1.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 0.8 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 0.6 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.1 0.6 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.2 0.5 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.5 GO:0015705 iodide transport(GO:0015705)
0.0 0.5 GO:0097421 liver regeneration(GO:0097421)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.4 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.3 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0055037 recycling endosome(GO:0055037)
0.1 2.6 GO:0000800 lateral element(GO:0000800)
0.1 1.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.0 GO:0030690 Noc1p-Noc2p complex(GO:0030690)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 0.8 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.5 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 1.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 0.5 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis