Motif ID: Pax8

Z-value: 0.543


Transcription factors associated with Pax8:

Gene SymbolEntrez IDGene Name
Pax8 ENSMUSG00000026976.9 Pax8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax8mm10_v2_chr2_-_24475564_24475580-0.279.0e-02Click!


Activity profile for motif Pax8.

activity profile for motif Pax8


Sorted Z-values histogram for motif Pax8

Sorted Z-values for motif Pax8



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax8

PNG image of the network

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Top targets:


Showing 1 to 20 of 43 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_6961160 2.681 ENSMUST00000054055.6
 Usp29
ubiquitin specific peptidase 29
chr7_-_42578588 2.554 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr18_-_12121460 2.287 ENSMUST00000055447.6
ENSMUST00000050228.7
ENSMUST00000092075.4
 Tmem241


transmembrane protein 241


chr7_+_114768736 1.872 ENSMUST00000117543.1
 Insc
inscuteable homolog (Drosophila)
chr17_+_45555693 1.780 ENSMUST00000024742.7
 Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
chr9_-_103230415 1.627 ENSMUST00000035158.9
 Trf
transferrin
chr13_-_66852017 1.486 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr11_-_69801716 1.175 ENSMUST00000011285.4
ENSMUST00000102585.1
 Fgf11

fibroblast growth factor 11

chr12_+_71048338 1.077 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr7_+_112742025 1.067 ENSMUST00000164363.1
 Tead1
TEA domain family member 1
chr18_-_66860458 1.005 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr11_+_78499087 0.949 ENSMUST00000017488.4
 Vtn
vitronectin
chr7_-_42706369 0.948 ENSMUST00000180131.1
 Gm17067
predicted gene 17067
chr1_+_65186727 0.917 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing

chr2_+_128967383 0.847 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr9_+_32116040 0.844 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32
chr7_-_29906087 0.776 ENSMUST00000053521.8
 Zfp27
zinc finger protein 27
chr17_+_21691860 0.706 ENSMUST00000072133.4
 Gm10226
predicted gene 10226
chr19_+_46075842 0.684 ENSMUST00000165017.1
 Nolc1
nucleolar and coiled-body phosphoprotein 1
chr10_+_18845071 0.590 ENSMUST00000019998.7
 Perp
PERP, TP53 apoptosis effector

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0016579 protein deubiquitination(GO:0016579)
0.5 2.3 GO:0072530 purine-containing compound transmembrane transport(GO:0072530)
0.3 2.1 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 1.9 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.4 1.8 GO:0032329 serine transport(GO:0032329)
0.3 1.3 GO:0002024 diet induced thermogenesis(GO:0002024)
0.2 1.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 1.1 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 0.9 GO:0097421 liver regeneration(GO:0097421)
0.0 0.9 GO:0032288 myelin assembly(GO:0032288)
0.1 0.7 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.6 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.1 0.6 GO:0002934 desmosome organization(GO:0002934)
0.0 0.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.3 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.1 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.2 GO:0060414 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865) aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0001650 fibrillar center(GO:0001650)
0.3 2.1 GO:0097433 dense body(GO:0097433)
0.3 1.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 1.1 GO:0015030 Cajal body(GO:0015030)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 0.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.9 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 2.3 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.3 2.1 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 1.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.2 GO:0008083 growth factor activity(GO:0008083)
0.1 1.1 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 1.0 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.9 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.3 GO:2001069 glycogen binding(GO:2001069)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 0.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 1.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions