Motif ID: Pbx1_Pbx3

Z-value: 1.252

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx1mm10_v2_chr1_-_168432270_168432347-0.202.2e-01Click!
Pbx3mm10_v2_chr2_-_34372004_343720440.105.2e-01Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_63711969 8.852 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr17_+_85620816 7.879 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr13_+_15463837 6.716 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr19_+_55741810 6.518 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_-_36104060 6.230 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chrX_-_60893430 5.587 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr16_+_30065333 5.523 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr17_+_83215271 5.062 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic
chr17_+_85621017 4.806 ENSMUST00000162695.2
 Six3
sine oculis-related homeobox 3
chr4_-_3938354 4.329 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr17_-_85688252 4.302 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chr4_-_43523388 4.242 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chrX_-_141474034 4.175 ENSMUST00000101205.2
 Col4a6
collagen, type IV, alpha 6
chr17_-_70853482 4.124 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr11_-_19018956 3.841 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr14_-_48667508 3.693 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr19_-_9899450 3.684 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr13_-_64153194 3.646 ENSMUST00000059817.4
ENSMUST00000117241.1
 Zfp367

zinc finger protein 367

chr8_-_115707778 3.598 ENSMUST00000109104.1
 Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr11_-_22001605 3.591 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 13.9 GO:0048625 myoblast fate commitment(GO:0048625)
4.2 12.7 GO:0097402 neuroblast migration(GO:0097402)
3.0 8.9 GO:0044413 regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 7.9 GO:0007015 actin filament organization(GO:0007015)
2.2 6.7 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.3 6.7 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
1.0 6.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.2 6.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.3 5.6 GO:0007530 sex determination(GO:0007530)
1.8 5.5 GO:0021557 oculomotor nerve development(GO:0021557)
0.8 5.1 GO:0090005 negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
1.1 4.3 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.3 4.3 GO:0060736 prostate gland growth(GO:0060736)
0.3 4.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 4.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 3.9 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.9 3.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.7 3.6 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.1 3.5 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.7 3.3 GO:0021764 amygdala development(GO:0021764)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 13.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 13.9 GO:0016607 nuclear speck(GO:0016607)
0.8 10.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
1.8 8.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
0.2 6.7 GO:0016592 mediator complex(GO:0016592)
0.8 4.2 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 4.0 GO:0016363 nuclear matrix(GO:0016363)
1.2 3.7 GO:0000801 central element(GO:0000801)
0.4 3.5 GO:0072687 meiotic spindle(GO:0072687)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.8 GO:0005604 basement membrane(GO:0005604)
0.0 2.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.4 GO:0030496 midbody(GO:0030496)
0.5 2.2 GO:0008623 CHRAC(GO:0008623)
0.4 2.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 2.0 GO:0000922 spindle pole(GO:0000922)
0.6 1.8 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.2 1.8 GO:0016593 Cdc73/Paf1 complex(GO:0016593)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.7 14.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.5 13.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 11.0 GO:0008307 structural constituent of muscle(GO:0008307)
1.8 8.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 8.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 8.2 GO:0042826 histone deacetylase binding(GO:0042826)
0.3 7.9 GO:0008432 JUN kinase binding(GO:0008432)
0.1 6.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 5.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 4.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.6 4.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 3.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 2.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 2.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 2.4 GO:0043426 MRF binding(GO:0043426)
0.2 2.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 2.0 GO:0043015 gamma-tubulin binding(GO:0043015)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 9.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 8.8 PID_PLK1_PATHWAY PLK1 signaling events
0.2 7.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 6.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 5.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 3.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 1.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.4 8.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 6.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 5.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 5.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 5.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 5.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 4.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 2.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 2.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.7 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac