Motif ID: Pbx2

Z-value: 0.639


Transcription factors associated with Pbx2:

Gene SymbolEntrez IDGene Name
Pbx2 ENSMUSG00000034673.8 Pbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx2mm10_v2_chr17_+_34593388_34593417-0.552.0e-04Click!


Activity profile for motif Pbx2.

activity profile for motif Pbx2


Sorted Z-values histogram for motif Pbx2

Sorted Z-values for motif Pbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 134 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 3.858 ENSMUST00000100572.3
 Sla
src-like adaptor
chr5_+_106609098 2.455 ENSMUST00000167618.1
 Gm17304
predicted gene, 17304
chr3_+_121953213 2.402 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr9_-_54661870 2.255 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr1_-_56972437 2.253 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr17_+_78508063 2.162 ENSMUST00000024880.9
 Vit
vitrin
chr9_-_54661666 1.764 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr11_-_79504078 1.681 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr6_+_8259288 1.597 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr15_+_21111452 1.590 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr8_+_72646679 1.526 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr8_+_72646728 1.348 ENSMUST00000161254.1
 Nwd1
NACHT and WD repeat domain containing 1
chr3_-_152982240 1.343 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr2_-_104257400 1.310 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr14_+_65969714 1.220 ENSMUST00000153460.1
 Clu
clusterin
chr6_-_8259098 1.185 ENSMUST00000012627.4
 Rpa3
replication protein A3
chr11_+_3330401 1.160 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr11_+_3330781 1.129 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chrX_+_140367494 1.092 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr3_+_68572245 1.035 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 3.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 2.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 2.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 2.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.7 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 1.4 GO:0006298 mismatch repair(GO:0006298)
0.1 1.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 1.2 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 1.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.0 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 1.0 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.0 GO:0001553 luteinization(GO:0001553)
0.1 0.6 GO:0006547 histidine metabolic process(GO:0006547)
0.0 0.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 0.5 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.5 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 0.4 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 4.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.9 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 1.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 0.9 GO:0033269 internode region of axon(GO:0033269)
0.0 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.4 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.8 2.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 1.6 GO:0030165 PDZ domain binding(GO:0030165)
0.2 1.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 1.1 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 0.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.6 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.5 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.2 GO:0003996 acyl-CoA ligase activity(GO:0003996) fatty-acyl-CoA synthase activity(GO:0004321)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 3.2 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 2.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 1.6 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.3 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.1 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.1 1.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.5 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects