Motif ID: Pitx1

Z-value: 0.613


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_18818895 1.961 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr13_-_97747399 1.951 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr4_+_144892813 1.908 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 1.701 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_-_15879844 1.585 ENSMUST00000172758.1
ENSMUST00000044434.6
 Crx

cone-rod homeobox containing gene

chr2_+_102658640 1.565 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_+_144893127 1.548 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_-_84270782 1.540 ENSMUST00000054990.4
 Trim2
tripartite motif-containing 2
chr1_-_155232710 1.459 ENSMUST00000035914.3
 BC034090
cDNA sequence BC034090
chr6_+_4902913 1.414 ENSMUST00000175889.1
ENSMUST00000168998.2
 Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr7_-_80403315 1.404 ENSMUST00000147150.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr14_+_64588112 1.269 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr16_-_46010212 1.193 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr5_+_3343893 1.099 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr3_+_89520152 1.085 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr2_+_119325784 1.069 ENSMUST00000102517.3
 Dll4
delta-like 4 (Drosophila)
chrX_+_169879596 1.068 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr10_+_69925484 1.056 ENSMUST00000182692.1
ENSMUST00000092433.5
 Ank3

ankyrin 3, epithelial

chr6_+_4903350 1.034 ENSMUST00000175962.1
 Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr1_-_165934900 1.033 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
 Pou2f1


POU domain, class 2, transcription factor 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.2 GO:0042572 retinol metabolic process(GO:0042572)
0.4 4.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.1 3.2 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.0 2.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.7 GO:0016042 lipid catabolic process(GO:0016042)
0.3 1.9 GO:0044838 cell quiescence(GO:0044838)
0.2 1.8 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 1.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2 1.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 1.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.4 1.4 GO:0090472 dibasic protein processing(GO:0090472)
0.4 1.2 GO:1904978 regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.4 1.1 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 1.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.0 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.9 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 0.9 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.9 GO:0007602 phototransduction(GO:0007602)
0.3 0.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.7 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.0 GO:0033270 paranode region of axon(GO:0033270)
0.6 3.2 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 2.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.8 GO:0030175 filopodium(GO:0030175)
0.0 1.6 GO:0030673 axolemma(GO:0030673)
0.1 1.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.0 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 1.0 GO:0010369 chromocenter(GO:0010369)
0.0 1.0 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 0.9 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.8 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.6 GO:0042382 paraspeckles(GO:0042382)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 0.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 3.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.6 1.9 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 1.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 1.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.3 1.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 1.5 GO:0017022 myosin binding(GO:0017022)
0.1 1.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 1.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 1.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.3 1.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 1.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 0.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 0.9 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 0.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.3 0.8 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.8 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.8 GO:0005049 nuclear export signal receptor activity(GO:0005049)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.2 ST_GAQ_PATHWAY G alpha q Pathway
0.0 1.2 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.8 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 0.7 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.5 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.1 0.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 1.4 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.0 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.9 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.7 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 0.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 0.3 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation