Motif ID: Pitx2_Otx2

Z-value: 1.706

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx2mm10_v2_chr14_-_48665098_486652460.508.2e-04Click!
Pitx2mm10_v2_chr3_+_129213920_1292139380.381.5e-02Click!


Activity profile for motif Pitx2_Otx2.

activity profile for motif Pitx2_Otx2


Sorted Z-values histogram for motif Pitx2_Otx2

Sorted Z-values for motif Pitx2_Otx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_75782080 16.136 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr2_+_164562579 12.890 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr6_-_88898664 10.500 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr11_-_106998483 10.188 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr16_+_30065333 8.841 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr14_-_20181773 8.270 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr9_+_119357381 7.887 ENSMUST00000039610.8
 Xylb
xylulokinase homolog (H. influenzae)
chr17_+_35861318 7.620 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr9_-_70421533 7.520 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr1_+_135232045 7.104 ENSMUST00000110798.3
 Gm4204
predicted gene 4204
chr11_-_60811228 6.974 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr18_+_34751803 6.942 ENSMUST00000181453.1
ENSMUST00000181641.1
 2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr1_-_175979114 6.693 ENSMUST00000104983.1
 B020018G12Rik
RIKEN cDNA B020018G12 gene
chr5_-_135251209 6.688 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr7_+_16781341 6.668 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr18_-_60501983 6.574 ENSMUST00000042710.6
 Smim3
small integral membrane protein 3
chr8_+_33653238 6.398 ENSMUST00000033992.8
 Gsr
glutathione reductase
chr4_-_117182623 6.385 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr19_-_41896132 5.998 ENSMUST00000038677.3
 Rrp12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr17_+_80127447 5.793 ENSMUST00000039205.4
 Galm
galactose mutarotase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 405 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 19.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 14.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.3 11.9 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
1.0 10.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.2 9.6 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.4 9.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
3.0 9.0 GO:0042732 D-xylose metabolic process(GO:0042732)
2.9 8.8 GO:0021557 oculomotor nerve development(GO:0021557)
0.3 8.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.8 8.3 GO:0030322 stabilization of membrane potential(GO:0030322)
2.0 8.0 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 7.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 7.2 GO:0006749 glutathione metabolic process(GO:0006749)
2.2 6.7 GO:1990523 bone regeneration(GO:1990523)
0.2 6.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.6 6.5 GO:0015825 L-serine transport(GO:0015825)
1.3 6.5 GO:0015705 iodide transport(GO:0015705)
1.3 6.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 6.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.7 6.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 219 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 47.4 GO:0070062 extracellular exosome(GO:0070062)
0.5 39.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 23.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 19.8 GO:0005643 nuclear pore(GO:0005643)
0.3 13.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.8 13.5 GO:0005652 nuclear lamina(GO:0005652)
1.6 12.9 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 12.7 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 11.9 GO:0016607 nuclear speck(GO:0016607)
0.0 10.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.6 9.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 9.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.9 9.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 8.7 GO:0005581 collagen trimer(GO:0005581)
1.1 7.7 GO:0001940 male pronucleus(GO:0001940)
0.4 7.6 GO:0031527 filopodium membrane(GO:0031527)
0.1 7.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 6.8 GO:0005871 kinesin complex(GO:0005871)
0.1 6.7 GO:0016363 nuclear matrix(GO:0016363)
0.2 6.5 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 284 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 59.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 17.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
2.6 12.9 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 11.8 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.7 10.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 10.2 GO:0045296 cadherin binding(GO:0045296)
0.5 10.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
3.2 9.6 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.4 9.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.6 8.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 8.8 GO:0008432 JUN kinase binding(GO:0008432)
0.8 8.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 8.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
2.7 8.0 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 7.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 7.5 GO:0005198 structural molecule activity(GO:0005198)
1.2 7.0 GO:0042731 PH domain binding(GO:0042731)
0.0 6.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 6.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 6.6 GO:0070034 telomerase RNA binding(GO:0070034)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.7 PID_ATR_PATHWAY ATR signaling pathway
0.6 18.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 18.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 13.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 10.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 9.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 7.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 7.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 7.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 5.9 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 5.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 4.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 3.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.2 PID_E2F_PATHWAY E2F transcription factor network
0.3 3.1 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.1 3.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 2.9 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.3 2.6 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 59.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.4 24.4 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.2 19.6 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3 19.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 15.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.8 12.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.7 12.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 11.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 9.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 8.9 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 8.8 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.5 8.0 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.5 7.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.3 7.5 REACTOME_KINESINS Genes involved in Kinesins
0.3 7.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 7.4 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.3 7.3 REACTOME_MRNA_CAPPING Genes involved in mRNA Capping
0.3 6.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 6.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 6.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import