Motif ID: Pknox2_Pknox1

Z-value: 0.806

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox2mm10_v2_chr9_-_37147257_371473230.444.3e-03Click!
Pknox1mm10_v2_chr17_+_31564749_31564854-0.067.0e-01Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_113758638 5.062 ENSMUST00000099575.3
 Grem1
gremlin 1
chr5_-_134747241 4.047 ENSMUST00000015138.9
 Eln
elastin
chr2_-_34913976 3.568 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr11_+_78324200 3.531 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr9_+_44134562 3.504 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr5_-_109558957 2.559 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr18_+_56432116 2.329 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr2_+_105682463 2.326 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr7_-_131410325 2.143 ENSMUST00000154602.1
 Ikzf5
IKAROS family zinc finger 5
chr2_-_31141802 2.091 ENSMUST00000073879.5
ENSMUST00000100208.2
ENSMUST00000100207.2
ENSMUST00000113555.1
ENSMUST00000075326.4
ENSMUST00000113552.2
ENSMUST00000136181.1
 Fnbp1






formin binding protein 1






chr15_+_32920723 2.015 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr16_-_43979050 1.892 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr7_-_131410495 1.868 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr15_-_100599864 1.776 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr9_+_113930934 1.764 ENSMUST00000084885.5
ENSMUST00000009885.7
 Ubp1

upstream binding protein 1

chr11_+_78826575 1.716 ENSMUST00000147875.2
ENSMUST00000141321.1
 Lyrm9

LYR motif containing 9

chr18_+_49832622 1.612 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr2_-_116065047 1.521 ENSMUST00000028639.6
ENSMUST00000102538.4
 Meis2

Meis homeobox 2

chr2_-_31142002 1.461 ENSMUST00000113560.1
ENSMUST00000113564.2
ENSMUST00000113562.2
 Fnbp1


formin binding protein 1


chr7_+_112225856 1.453 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 5.1 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.0 4.0 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 4.0 GO:0051291 protein heterooligomerization(GO:0051291)
0.5 3.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.4 3.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 3.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.4 2.6 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.5 2.3 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.0 2.3 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 1.9 GO:0018345 protein palmitoylation(GO:0018345)
0.6 1.7 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.3 1.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.6 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.4 1.5 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.2 1.5 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.2 1.5 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 1.5 GO:0008542 visual learning(GO:0008542)
0.1 1.3 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.1 1.2 GO:0060736 prostate gland growth(GO:0060736)
0.1 1.1 GO:0036297 interstrand cross-link repair(GO:0036297)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.4 GO:0009986 cell surface(GO:0009986)
1.3 4.0 GO:0071953 elastic fiber(GO:0071953)
0.1 3.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 0.9 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.8 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.6 5.1 GO:0036122 BMP binding(GO:0036122)
0.1 4.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 3.6 GO:0035064 methylated histone binding(GO:0035064)
0.6 3.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 2.6 GO:0005125 cytokine activity(GO:0005125)
0.0 2.5 GO:0020037 heme binding(GO:0020037)
0.1 2.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.8 GO:0001221 transcription cofactor binding(GO:0001221)
0.4 1.6 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.4 1.5 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 1.5 GO:0071949 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949)
0.3 1.3 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.3 GO:0017022 myosin binding(GO:0017022)
0.2 0.9 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.9 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID_CDC42_PATHWAY CDC42 signaling events
0.1 1.1 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 2.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 2.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.4 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation