Motif ID: Plag1

Z-value: 0.582


Transcription factors associated with Plag1:

Gene SymbolEntrez IDGene Name
Plag1 ENSMUSG00000003282.3 Plag1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plag1mm10_v2_chr4_-_3938354_3938401-0.315.1e-02Click!


Activity profile for motif Plag1.

activity profile for motif Plag1


Sorted Z-values histogram for motif Plag1

Sorted Z-values for motif Plag1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plag1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_133498538 2.580 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr18_-_58209926 1.999 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr4_-_129121699 1.891 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr5_+_117841839 1.811 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr10_-_102490418 1.632 ENSMUST00000020040.3
 Nts
neurotensin
chr15_-_66801577 1.618 ENSMUST00000168589.1
 Sla
src-like adaptor
chr5_+_117781017 1.358 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr11_-_69369377 1.347 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr1_-_56969864 1.305 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr4_-_129121234 1.275 ENSMUST00000030572.3
 Hpca
hippocalcin
chr4_-_129121889 1.198 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr7_-_27446599 1.172 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr7_-_46099752 1.161 ENSMUST00000180081.1
 Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
chr5_-_89883321 1.137 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr3_+_89520152 1.122 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr7_-_46179929 1.085 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr1_-_56969827 1.056 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr3_+_117575268 1.012 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr1_+_75382114 1.005 ENSMUST00000113590.1
ENSMUST00000148515.1
 Speg

SPEG complex locus

chr5_-_37717122 0.972 ENSMUST00000094836.4
 Stk32b
serine/threonine kinase 32B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 255 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0021696 cerebellar cortex morphogenesis(GO:0021696)
1.5 4.4 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
1.1 3.2 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.2 3.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 2.0 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.3 2.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 2.0 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 1.9 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 1.9 GO:0008542 visual learning(GO:0008542)
0.0 1.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 1.5 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.3 1.5 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.2 1.5 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.1 1.4 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 1.3 GO:0060347 heart trabecula formation(GO:0060347)
0.1 1.3 GO:0033198 response to ATP(GO:0033198)
0.0 1.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 1.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.4 1.1 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.2 1.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.8 GO:0044327 dendritic spine head(GO:0044327)
0.0 3.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.4 GO:0097060 synaptic membrane(GO:0097060)
0.3 2.8 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.6 2.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.4 2.4 GO:0008091 spectrin(GO:0008091)
0.0 2.2 GO:0031594 neuromuscular junction(GO:0031594)
0.2 2.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 1.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.5 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.4 1.1 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.0 1.1 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.0 GO:0043196 varicosity(GO:0043196)
0.0 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.0 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.9 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 1.8 GO:0000149 SNARE binding(GO:0000149)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 1.5 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.4 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 1.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 1.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 1.1 GO:0019841 retinol binding(GO:0019841)
0.3 1.0 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 0.9 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 0.9 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 0.9 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.9 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.1 0.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.3 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 1.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.0 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.5 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 3.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.4 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.1 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism
0.1 1.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.0 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 0.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.8 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.8 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex