Motif ID: Pou1f1

Z-value: 0.768


Transcription factors associated with Pou1f1:

Gene SymbolEntrez IDGene Name
Pou1f1 ENSMUSG00000004842.12 Pou1f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou1f1mm10_v2_chr16_+_65520503_65520548-0.115.1e-01Click!


Activity profile for motif Pou1f1.

activity profile for motif Pou1f1


Sorted Z-values histogram for motif Pou1f1

Sorted Z-values for motif Pou1f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou1f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 7.727 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr7_-_103853199 6.159 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr1_+_107511416 4.361 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_110099295 3.386 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr1_+_107511489 3.183 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr9_-_79977782 2.269 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr1_-_75278345 2.182 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr17_+_21690766 2.175 ENSMUST00000097384.1
 Gm10509
predicted gene 10509
chr1_+_66364623 1.946 ENSMUST00000077355.5
ENSMUST00000114012.1
 Map2

microtubule-associated protein 2

chr1_+_109993982 1.838 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr5_-_53707532 1.821 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr7_-_14562171 1.700 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr7_-_103843154 1.687 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr2_+_164074122 1.677 ENSMUST00000018353.7
 Stk4
serine/threonine kinase 4
chr7_-_28008416 1.660 ENSMUST00000180024.1
 Zfp850
zinc finger protein 850
chr13_-_14523178 1.621 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr10_-_116972609 1.518 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr6_-_113719880 1.444 ENSMUST00000064993.5
 Ghrl
ghrelin
chr14_-_37098211 1.319 ENSMUST00000022337.9
 Cdhr1
cadherin-related family member 1
chr1_+_109983737 1.315 ENSMUST00000172005.1
 Cdh7
cadherin 7, type 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 7.8 GO:0015671 oxygen transport(GO:0015671)
0.1 7.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 5.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 3.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.7 2.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 2.1 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.6 1.8 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.5 1.8 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.4 1.7 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 1.6 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.3 GO:0006020 inositol metabolic process(GO:0006020)
0.4 1.2 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.2 1.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 1.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.1 GO:0019321 pentose metabolic process(GO:0019321)
0.0 1.1 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.2 1.0 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 1.0 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.0 GO:1902913 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of neuroepithelial cell differentiation(GO:1902913)
0.1 1.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.8 GO:0005833 hemoglobin complex(GO:0005833)
0.3 3.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 2.3 GO:0043195 terminal bouton(GO:0043195)
0.4 2.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 2.0 GO:0031045 dense core granule(GO:0031045)
0.0 1.7 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.5 GO:0032009 early phagosome(GO:0032009)
0.1 1.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 1.0 GO:0097149 centralspindlin complex(GO:0097149)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.9 GO:0072686 mitotic spindle(GO:0072686)
0.3 0.8 GO:0070985 TFIIK complex(GO:0070985)
0.1 0.8 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.8 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.2 0.7 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.7 GO:0070069 cytochrome complex(GO:0070069)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 7.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 6.9 GO:0005509 calcium ion binding(GO:0005509)
0.1 5.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 3.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 2.7 GO:0017124 SH3 domain binding(GO:0017124)
0.5 1.6 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 1.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.6 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.5 GO:0050699 WW domain binding(GO:0050699)
0.1 1.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.4 1.2 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.2 1.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 1.1 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.3 1.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 1.0 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.9 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.4 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 2.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 1.7 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 1.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.8 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 0.7 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation