Motif ID: Pou2f2_Pou3f1

Z-value: 2.204

Transcription factors associated with Pou2f2_Pou3f1:

Gene SymbolEntrez IDGene Name
Pou2f2 ENSMUSG00000008496.12 Pou2f2
Pou3f1 ENSMUSG00000090125.2 Pou3f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f1mm10_v2_chr4_+_124657646_124657656-0.824.3e-11Click!
Pou2f2mm10_v2_chr7_-_25132473_25132512-0.587.8e-05Click!


Activity profile for motif Pou2f2_Pou3f1.

activity profile for motif Pou2f2_Pou3f1


Sorted Z-values histogram for motif Pou2f2_Pou3f1

Sorted Z-values for motif Pou2f2_Pou3f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou2f2_Pou3f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_67234620 21.616 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr6_+_8949670 19.166 ENSMUST00000060369.3
 Nxph1
neurexophilin 1
chr17_-_58991343 18.846 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr7_+_45017953 18.329 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr7_+_24507122 17.047 ENSMUST00000177205.1
 Zfp428
zinc finger protein 428
chr2_-_36105271 16.708 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr7_+_24507057 14.872 ENSMUST00000071361.6
 Zfp428
zinc finger protein 428
chr7_+_24507006 14.478 ENSMUST00000176880.1
 Zfp428
zinc finger protein 428
chr13_-_56252163 14.366 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr13_+_23746734 13.803 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr2_+_25180737 13.395 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr7_+_24507099 13.245 ENSMUST00000177228.1
 Zfp428
zinc finger protein 428
chr2_+_71528657 12.599 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr12_+_89812467 12.400 ENSMUST00000110133.2
ENSMUST00000110130.2
 Nrxn3

neurexin III

chr8_-_47990535 11.659 ENSMUST00000057561.7
 Wwc2
WW, C2 and coiled-coil domain containing 2
chr2_-_58052832 11.480 ENSMUST00000090940.5
 Ermn
ermin, ERM-like protein
chr8_+_68880491 11.007 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr8_-_46294592 10.840 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr6_-_67037399 10.782 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr13_+_21722057 10.719 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 57.2 GO:0006342 chromatin silencing(GO:0006342)
0.3 31.4 GO:0006334 nucleosome assembly(GO:0006334)
2.5 30.2 GO:0002227 innate immune response in mucosa(GO:0002227)
2.6 28.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.3 21.6 GO:0035563 positive regulation of chromatin binding(GO:0035563)
3.4 20.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.4 18.3 GO:0060325 face morphogenesis(GO:0060325)
0.4 18.0 GO:0006284 base-excision repair(GO:0006284)
1.3 16.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
3.6 14.4 GO:0021648 zygotic determination of anterior/posterior axis, embryo(GO:0007354) cranial nerve formation(GO:0021603) vestibulocochlear nerve morphogenesis(GO:0021648)
3.6 14.3 GO:0045608 inhibition of neuroepithelial cell differentiation(GO:0002085) negative regulation of auditory receptor cell differentiation(GO:0045608)
0.1 14.0 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
1.7 13.4 GO:0014807 regulation of somitogenesis(GO:0014807)
2.6 13.0 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) positive regulation of cell fate specification(GO:0042660) sensory neuron migration(GO:1904937)
1.1 13.0 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
4.2 12.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.3 12.0 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
1.7 11.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
2.8 11.0 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.5 10.8 GO:0001967 suckling behavior(GO:0001967)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 52.5 GO:0000790 nuclear chromatin(GO:0000790)
0.7 52.3 GO:0000786 nucleosome(GO:0000786)
0.0 48.3 GO:0005615 extracellular space(GO:0005615)
0.1 36.0 GO:0005912 adherens junction(GO:0005912)
2.6 18.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 15.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 15.1 GO:0032993 protein-DNA complex(GO:0032993)
1.4 11.5 GO:0033269 internode region of axon(GO:0033269)
1.6 11.0 GO:0042627 chylomicron(GO:0042627)
0.0 10.4 GO:0016607 nuclear speck(GO:0016607)
0.1 9.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.3 9.2 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 8.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 8.1 GO:0043209 myelin sheath(GO:0043209)
0.1 7.6 GO:0043204 perikaryon(GO:0043204)
0.5 7.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 7.0 GO:0030496 midbody(GO:0030496)
0.1 6.8 GO:0042734 presynaptic membrane(GO:0042734)
0.3 6.0 GO:0035102 PRC1 complex(GO:0035102)
1.9 5.6 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 71.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 58.0 GO:0003677 DNA binding(GO:0003677)
0.1 55.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 36.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 31.4 GO:0003676 nucleic acid binding(GO:0003676)
1.9 30.9 GO:0003680 AT DNA binding(GO:0003680)
0.3 18.3 GO:0019003 GDP binding(GO:0019003)
0.1 14.9 GO:0051015 actin filament binding(GO:0051015)
0.3 12.4 GO:0070888 E-box binding(GO:0070888)
1.1 12.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.0 11.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 11.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6 9.8 GO:0030957 Tat protein binding(GO:0030957)
1.0 8.8 GO:0061133 endopeptidase activator activity(GO:0061133)
1.9 7.8 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
1.4 7.0 GO:0043515 kinetochore binding(GO:0043515)
1.0 6.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.4 6.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 6.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 6.5 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 32.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 19.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.3 18.3 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.6 16.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.3 15.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.2 14.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 10.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 9.8 PID_CDC42_PATHWAY CDC42 signaling events
0.3 7.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.2 7.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 7.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.5 6.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 6.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 6.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.3 6.0 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 3.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 93.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
1.1 18.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
2.2 18.0 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.9 13.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 11.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.8 11.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.7 9.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 9.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 7.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 7.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 6.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 6.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 6.0 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3 5.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.4 5.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.4 4.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.5 3.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.0 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism