Motif ID: Pou3f2

Z-value: 0.662


Transcription factors associated with Pou3f2:

Gene SymbolEntrez IDGene Name
Pou3f2 ENSMUSG00000095139.1 Pou3f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f2mm10_v2_chr4_-_22488296_224883660.251.1e-01Click!


Activity profile for motif Pou3f2.

activity profile for motif Pou3f2


Sorted Z-values histogram for motif Pou3f2

Sorted Z-values for motif Pou3f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f2

PNG image of the network

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Top targets:


Showing 1 to 20 of 121 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_103843685 2.860 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr14_-_103844173 2.834 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr11_+_23256566 2.170 ENSMUST00000136235.1
 Xpo1
exportin 1, CRM1 homolog (yeast)
chr3_+_141465564 1.874 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr18_+_5593566 1.839 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr14_-_47418407 1.578 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr18_+_4920509 1.422 ENSMUST00000126977.1
 Svil
supervillin
chr6_+_90465287 1.344 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr14_+_99046406 1.321 ENSMUST00000022656.6
 Bora
bora, aurora kinase A activator
chr17_-_46032366 1.262 ENSMUST00000071648.5
ENSMUST00000142351.2
ENSMUST00000167860.1
 Vegfa


vascular endothelial growth factor A


chr3_+_88965812 1.131 ENSMUST00000090933.4
 Ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr4_-_110286581 1.105 ENSMUST00000138972.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_-_162159717 1.091 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr17_-_46031813 1.081 ENSMUST00000024747.7
 Vegfa
vascular endothelial growth factor A
chr18_-_74961252 1.045 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr3_+_141465592 0.998 ENSMUST00000130636.1
 Unc5c
unc-5 homolog C (C. elegans)
chr7_+_75610038 0.926 ENSMUST00000125771.1
 Akap13
A kinase (PRKA) anchor protein 13
chr9_+_44981779 0.917 ENSMUST00000034602.7
 Cd3d
CD3 antigen, delta polypeptide
chr1_+_74661794 0.883 ENSMUST00000129890.1
 Ttll4
tubulin tyrosine ligase-like family, member 4
chr3_-_36571952 0.877 ENSMUST00000029270.3
 Ccna2
cyclin A2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.7 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.4 2.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.3 2.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.8 2.3 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.2 1.8 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.2 1.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.3 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 1.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 1.1 GO:0002674 negative regulation of acute inflammatory response(GO:0002674)
0.0 1.1 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 1.1 GO:0043488 regulation of mRNA stability(GO:0043488)
0.3 1.0 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 0.9 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.9 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.9 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.9 GO:0046677 response to antibiotic(GO:0046677)
0.3 0.8 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.2 0.8 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 0.8 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.7 GO:0005642 annulate lamellae(GO:0005642)
0.0 2.3 GO:0005604 basement membrane(GO:0005604)
0.1 1.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.1 1.3 GO:0072687 meiotic spindle(GO:0072687)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.2 0.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.9 GO:0001940 male pronucleus(GO:0001940)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 0.8 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.8 GO:0005902 microvillus(GO:0005902)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.7 GO:0004962 endothelin receptor activity(GO:0004962)
0.5 2.9 GO:0005042 netrin receptor activity(GO:0005042)
0.3 2.7 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.8 2.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.2 1.6 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 1.2 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.2 1.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 1.1 GO:0017091 AU-rich element binding(GO:0017091)
0.3 1.0 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 0.8 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.8 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.8 GO:0005080 protein kinase C binding(GO:0005080)
0.2 0.7 GO:0042936 dipeptide transporter activity(GO:0042936)
0.1 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.7 GO:0043495 protein anchor(GO:0043495)
0.0 0.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 0.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 2.8 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 2.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 3.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 2.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 2.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 0.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.8 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins