Motif ID: Pou3f4

Z-value: 0.526


Transcription factors associated with Pou3f4:

Gene SymbolEntrez IDGene Name
Pou3f4 ENSMUSG00000056854.3 Pou3f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f4mm10_v2_chrX_+_110814390_110814413-0.153.6e-01Click!


Activity profile for motif Pou3f4.

activity profile for motif Pou3f4


Sorted Z-values histogram for motif Pou3f4

Sorted Z-values for motif Pou3f4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_110061319 2.845 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr16_-_22439719 2.579 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr19_+_55741810 2.323 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr3_+_68869563 2.211 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr3_-_57575760 2.019 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575907 1.959 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr19_+_55742242 1.735 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr18_-_74961252 1.735 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr17_-_58991343 1.690 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr16_-_22439570 1.642 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr15_-_79285502 1.615 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr4_+_15881255 1.539 ENSMUST00000029876.1
 Calb1
calbindin 1
chr2_+_25180737 1.062 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr6_-_36811361 1.055 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr19_+_55741884 1.004 ENSMUST00000111658.3
ENSMUST00000111654.1
 Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr19_+_55742056 0.877 ENSMUST00000111659.2
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr18_+_33794882 0.865 ENSMUST00000146010.2
 2410004N09Rik
RIKEN cDNA 2410004N09 gene
chr5_+_137350371 0.862 ENSMUST00000166239.1
ENSMUST00000111054.1
 Ephb4

Eph receptor B4

chr19_+_37436707 0.830 ENSMUST00000128184.1
 Hhex
hematopoietically expressed homeobox
chr3_+_94933041 0.804 ENSMUST00000090839.5
 Selenbp1
selenium binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.9 GO:0048625 myoblast fate commitment(GO:0048625)
0.8 4.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.6 4.0 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.4 1.7 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 1.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.8 1.5 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.4 1.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 1.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 1.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 0.9 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.2 0.8 GO:0061010 gall bladder development(GO:0061010)
0.1 0.8 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.8 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.7 GO:0040031 snRNA modification(GO:0040031)
0.0 0.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 0.6 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.6 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 0.5 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.0 GO:0001650 fibrillar center(GO:0001650)
0.2 1.6 GO:0071439 clathrin complex(GO:0071439)
0.0 1.5 GO:0043195 terminal bouton(GO:0043195)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 0.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.4 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 3.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.0 GO:0005496 steroid binding(GO:0005496)
0.4 1.7 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 1.6 GO:0008430 selenium binding(GO:0008430)
0.4 1.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.9 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 0.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.7 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.2 0.6 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.1 0.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.4 GO:0004568 chitinase activity(GO:0004568)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 3.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.8 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 0.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.1 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation