Motif ID: Pou5f1

Z-value: 1.339


Transcription factors associated with Pou5f1:

Gene SymbolEntrez IDGene Name
Pou5f1 ENSMUSG00000024406.10 Pou5f1



Activity profile for motif Pou5f1.

activity profile for motif Pou5f1


Sorted Z-values histogram for motif Pou5f1

Sorted Z-values for motif Pou5f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou5f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 11.086 ENSMUST00000164163.1
 Sla
src-like adaptor
chr8_-_84773381 10.685 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr8_+_54954728 8.778 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr4_+_97772734 8.297 ENSMUST00000152023.1
 Nfia
nuclear factor I/A
chr14_-_79771305 8.194 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr6_+_136518820 8.114 ENSMUST00000032335.6
 Atf7ip
activating transcription factor 7 interacting protein
chr5_+_129584169 6.750 ENSMUST00000031390.8
 Mmp17
matrix metallopeptidase 17
chr7_+_91090697 6.738 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 6.611 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr11_-_69605829 6.457 ENSMUST00000047889.6
 Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr15_-_100599864 6.314 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr3_-_80802789 6.295 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr5_+_66968559 6.237 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr5_+_66968961 6.191 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr14_-_102982630 5.812 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr14_-_88471396 5.717 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr12_+_29528382 5.483 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr8_+_118283719 5.059 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr7_-_78578308 4.974 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr5_+_64812336 4.892 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 16.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 16.0 GO:0001919 regulation of receptor recycling(GO:0001919)
1.0 13.3 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.4 13.0 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.8 11.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 11.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
2.4 9.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.6 9.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 8.9 GO:0030325 adrenal gland development(GO:0030325)
2.9 8.8 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.8 8.8 GO:0042118 endothelial cell activation(GO:0042118)
0.7 8.7 GO:0072189 ureter development(GO:0072189)
0.6 8.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.6 8.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.6 7.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.8 6.9 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
1.6 6.5 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.6 5.8 GO:0042756 drinking behavior(GO:0042756)
0.1 5.5 GO:0006376 mRNA splice site selection(GO:0006376)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.7 13.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.8 12.8 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 11.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 11.0 GO:0045211 postsynaptic membrane(GO:0045211)
1.6 9.7 GO:0044308 axonal spine(GO:0044308)
0.2 9.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 8.9 GO:0015629 actin cytoskeleton(GO:0015629)
0.4 8.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 7.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 6.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 6.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.9 6.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 6.4 GO:0034702 ion channel complex(GO:0034702)
0.2 6.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 6.3 GO:0005769 early endosome(GO:0005769)
0.2 6.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.5 4.8 GO:0000805 X chromosome(GO:0000805)
0.4 4.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.4 4.1 GO:0031088 platelet dense granule membrane(GO:0031088)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 16.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 13.8 GO:0003779 actin binding(GO:0003779)
0.6 13.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 11.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 9.7 GO:0005262 calcium channel activity(GO:0005262)
3.2 9.6 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.0 9.3 GO:0016887 ATPase activity(GO:0016887)
2.9 8.8 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
2.2 8.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 8.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
1.2 8.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 8.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.5 7.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 7.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 6.9 GO:0031402 sodium ion binding(GO:0031402)
1.1 6.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.6 6.5 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.3 6.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 5.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 5.5 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 12.5 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 10.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 10.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.3 9.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 8.6 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.2 8.0 PID_ATR_PATHWAY ATR signaling pathway
0.1 7.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 6.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 6.3 PID_SHP2_PATHWAY SHP2 signaling
0.2 4.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 4.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.2 4.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 4.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 3.9 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.2 3.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 2.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 18.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4 14.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 9.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 6.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 6.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 6.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 4.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 4.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 4.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 4.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 3.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 3.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 2.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 2.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.7 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 2.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 2.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.3 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 2.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 2.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones