Motif ID: Pou6f2_Pou4f2

Z-value: 0.668

Transcription factors associated with Pou6f2_Pou4f2:

Gene SymbolEntrez IDGene Name
Pou4f2 ENSMUSG00000031688.3 Pou4f2
Pou6f2 ENSMUSG00000009734.11 Pou6f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou6f2mm10_v2_chr13_-_18382041_18382041-0.508.3e-04Click!
Pou4f2mm10_v2_chr8_-_78436640_784366490.038.7e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_56296551 7.377 ENSMUST00000021970.9
Cxcl14
chemokine (C-X-C motif) ligand 14
chr5_+_139543889 6.345 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr1_+_153665666 5.176 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr12_-_112511136 4.980 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr1_+_153665274 4.896 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr4_-_58499398 3.790 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr1_+_153665587 3.679 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr1_+_153665627 3.529 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr7_-_49636847 3.467 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr3_+_55782500 2.466 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr2_-_168767029 2.307 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr12_-_56535047 2.185 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr6_-_138426735 2.134 ENSMUST00000162932.1
Lmo3
LIM domain only 3
chr2_-_168767136 1.868 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr8_-_61902669 1.805 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr1_-_72874877 1.668 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr10_-_92164666 1.577 ENSMUST00000183123.1
ENSMUST00000182033.1
Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr14_+_27039001 1.540 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr19_+_24875679 1.522 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr6_-_138422898 1.519 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3



Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 17.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
2.5 7.4 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.8 6.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 4.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.4 4.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 4.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.9 3.8 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 3.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.4 2.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 2.6 GO:0003334 keratinocyte development(GO:0003334)
0.4 2.5 GO:0019532 oxalate transport(GO:0019532)
0.7 2.2 GO:0021759 globus pallidus development(GO:0021759)
0.2 1.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 1.3 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 1.3 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 1.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 1.3 GO:0008585 female gonad development(GO:0008585)
0.2 1.2 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.4 1.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.4 1.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 4.2 GO:0000792 heterochromatin(GO:0000792)
0.0 3.8 GO:0043198 dendritic shaft(GO:0043198)
0.2 2.7 GO:0043196 varicosity(GO:0043196)
0.0 1.8 GO:0002102 podosome(GO:0002102)
0.4 1.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 1.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.2 1.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.6 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.0 0.5 GO:0097542 ciliary tip(GO:0097542)
0.0 0.5 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 17.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 7.4 GO:0008009 chemokine activity(GO:0008009)
0.6 4.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 2.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 2.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 2.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 2.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 1.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 1.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 1.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.3 GO:0070628 proteasome binding(GO:0070628)
0.1 1.2 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.7 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.2 0.6 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.6 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 2.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.5 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.5 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.0 1.3 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.0 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling