Motif ID: Ppara

Z-value: 1.951


Transcription factors associated with Ppara:

Gene SymbolEntrez IDGene Name
Ppara ENSMUSG00000022383.7 Ppara



Activity profile for motif Ppara.

activity profile for motif Ppara


Sorted Z-values histogram for motif Ppara

Sorted Z-values for motif Ppara



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppara

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_9878998 12.289 ENSMUST00000063093.9
 Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr12_+_61523889 9.356 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr17_-_35909626 9.132 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr15_-_66801577 9.107 ENSMUST00000168589.1
 Sla
src-like adaptor
chr17_-_35910032 8.986 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr1_-_162478004 8.186 ENSMUST00000086074.5
ENSMUST00000070330.7
 Dnm3

dynamin 3

chr17_-_91088726 7.997 ENSMUST00000072671.7
ENSMUST00000174331.1
ENSMUST00000161402.3
ENSMUST00000054059.8
 Nrxn1



neurexin I



chr11_+_67586520 7.816 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr6_-_142964404 7.784 ENSMUST00000032421.3
 St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr15_+_100761741 7.608 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr11_+_67586675 7.477 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr5_+_150259922 7.295 ENSMUST00000087204.5
 Fry
furry homolog (Drosophila)
chr16_-_44139630 7.193 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr7_-_25005895 6.987 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr11_+_42419729 6.849 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr5_-_106696819 6.842 ENSMUST00000127434.1
ENSMUST00000112696.1
ENSMUST00000112698.1
 Zfp644


zinc finger protein 644


chr15_+_80091320 6.675 ENSMUST00000009728.6
ENSMUST00000009727.5
 Syngr1

synaptogyrin 1

chr7_+_91090728 6.624 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr12_+_109545390 6.479 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr11_-_6065538 6.333 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta







Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 342 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 19.0 GO:0071420 cellular response to histamine(GO:0071420)
0.4 18.2 GO:0006376 mRNA splice site selection(GO:0006376)
6.0 18.1 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.6 15.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
3.0 14.8 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 13.8 GO:0030041 actin filament polymerization(GO:0030041)
0.1 13.3 GO:0051260 protein homooligomerization(GO:0051260)
1.3 12.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.5 11.5 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.6 11.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
3.3 10.0 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
2.3 9.3 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.5 9.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.8 9.1 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.5 9.1 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.4 9.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 9.0 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 8.9 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.2 8.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 8.4 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 24.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 23.2 GO:0030427 site of polarized growth(GO:0030427)
0.2 22.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 18.7 GO:0031594 neuromuscular junction(GO:0031594)
0.9 18.4 GO:0032279 asymmetric synapse(GO:0032279)
0.1 16.5 GO:0060076 excitatory synapse(GO:0060076)
1.8 16.3 GO:0097427 microtubule bundle(GO:0097427)
0.1 16.3 GO:0005884 actin filament(GO:0005884)
0.4 14.3 GO:0032809 neuronal cell body membrane(GO:0032809)
1.4 12.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.4 12.1 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 12.0 GO:0005635 nuclear envelope(GO:0005635)
0.5 10.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 9.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.0 9.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 9.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9 8.7 GO:0044326 dendritic spine neck(GO:0044326)
0.2 8.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
2.0 8.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.4 8.2 GO:0031430 M band(GO:0031430)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 242 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 18.8 GO:0036002 pre-mRNA binding(GO:0036002)
3.0 18.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.0 17.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 16.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 15.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
3.0 14.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.5 14.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 13.1 GO:0017124 SH3 domain binding(GO:0017124)
0.2 12.9 GO:0030507 spectrin binding(GO:0030507)
0.0 12.7 GO:0005096 GTPase activator activity(GO:0005096)
1.0 11.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 9.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 9.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 9.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 8.9 GO:0016417 S-acyltransferase activity(GO:0016417)
0.6 8.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
2.7 8.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.4 7.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 7.5 GO:0043274 phospholipase binding(GO:0043274)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.2 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 13.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 9.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 6.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 6.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.6 PID_FGF_PATHWAY FGF signaling pathway
0.2 5.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 5.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.2 5.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 5.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 5.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 5.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 4.4 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 4.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 4.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 4.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 3.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 3.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 3.7 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 3.7 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 24.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.5 15.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3 13.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 13.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.5 12.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.4 10.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 10.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.7 9.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 8.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.9 7.5 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.3 7.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.4 6.7 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 6.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 5.8 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 5.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 5.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 5.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.4 5.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.2 5.0 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport