Motif ID: Pparg_Rxrg

Z-value: 1.191

Transcription factors associated with Pparg_Rxrg:

Gene SymbolEntrez IDGene Name
Pparg ENSMUSG00000000440.6 Pparg
Rxrg ENSMUSG00000015843.4 Rxrg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrgmm10_v2_chr1_+_167598384_167598411-0.221.6e-01Click!


Activity profile for motif Pparg_Rxrg.

activity profile for motif Pparg_Rxrg


Sorted Z-values histogram for motif Pparg_Rxrg

Sorted Z-values for motif Pparg_Rxrg



Network of associatons between targets according to the STRING database.



First level regulatory network of Pparg_Rxrg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_126556128 5.112 ENSMUST00000141482.2
 Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
chr4_-_126736236 3.406 ENSMUST00000048194.7
 Tfap2e
transcription factor AP-2, epsilon
chr11_-_100759942 3.244 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr6_+_34354119 3.159 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr4_+_9269285 3.122 ENSMUST00000038841.7
 Clvs1
clavesin 1
chr1_-_138847579 3.037 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr9_+_118506226 2.916 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr3_+_87948666 2.822 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr12_+_109452833 2.519 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr7_+_4925802 2.495 ENSMUST00000057612.7
 Ssc5d
scavenger receptor cysteine rich domain containing (5 domains)
chr2_+_165595009 2.387 ENSMUST00000088132.6
 Eya2
eyes absent 2 homolog (Drosophila)
chr14_+_54476100 2.265 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2

chr6_+_7844806 2.116 ENSMUST00000040159.4
 C1galt1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr2_-_79456750 2.114 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr2_-_117342831 2.110 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr9_-_106656081 1.777 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr17_+_32621319 1.714 ENSMUST00000077639.5
 Gm9705
predicted gene 9705
chr11_+_23666479 1.675 ENSMUST00000143117.1
 Pus10
pseudouridylate synthase 10
chr7_-_143756985 1.640 ENSMUST00000134056.1
 Osbpl5
oxysterol binding protein-like 5
chr9_-_37552904 1.601 ENSMUST00000065668.5
 Nrgn
neurogranin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 345 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 5.1 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.5 4.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 3.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.9 3.4 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.1 3.4 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
1.1 3.2 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.6 3.0 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 2.8 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.1 2.6 GO:2001222 regulation of neuron migration(GO:2001222)
0.4 2.5 GO:2000483 detection of bacterium(GO:0016045) detection of other organism(GO:0098543) negative regulation of interleukin-8 secretion(GO:2000483)
0.0 2.5 GO:0007605 sensory perception of sound(GO:0007605)
0.4 2.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 2.3 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 2.3 GO:0015914 phospholipid transport(GO:0015914)
0.1 2.2 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.5 2.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.4 2.1 GO:0016266 O-glycan processing(GO:0016266)
0.2 2.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.2 2.1 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.3 2.0 GO:1902302 regulation of potassium ion export(GO:1902302)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 3.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.5 GO:0030673 axolemma(GO:0030673)
0.1 2.2 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 2.2 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 2.1 GO:0030027 lamellipodium(GO:0030027)
0.0 2.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.8 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.7 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 1.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.7 GO:0005814 centriole(GO:0005814)
0.1 1.6 GO:0044327 dendritic spine head(GO:0044327)
0.0 1.6 GO:0031526 brush border membrane(GO:0031526)
0.2 1.5 GO:0001739 sex chromatin(GO:0001739)
0.1 1.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.5 1.4 GO:0071953 elastic fiber(GO:0071953)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 228 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 5.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 4.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.8 4.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 4.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 3.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 3.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 3.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 3.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 2.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.5 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 2.5 GO:0000287 magnesium ion binding(GO:0000287)
0.2 2.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 2.1 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 2.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 1.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.9 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 1.7 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 3.5 ST_STAT3_PATHWAY STAT3 Pathway
0.1 3.0 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.6 5.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 3.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.3 3.5 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.3 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 1.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.9 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.9 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.2 1.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.6 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.5 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation