Motif ID: Prop1

Z-value: 0.871


Transcription factors associated with Prop1:

Gene SymbolEntrez IDGene Name
Prop1 ENSMUSG00000044542.3 Prop1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prop1mm10_v2_chr11_-_50953745_50953768-0.241.3e-01Click!


Activity profile for motif Prop1.

activity profile for motif Prop1


Sorted Z-values histogram for motif Prop1

Sorted Z-values for motif Prop1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prop1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_45470201 8.016 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr13_+_94875600 6.699 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr1_+_107511416 5.089 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr3_+_146121655 4.434 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr16_-_16829276 4.224 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr12_+_79297345 3.938 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr15_-_56694525 3.876 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr17_+_27556613 3.696 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr17_+_27556668 3.651 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr1_+_6734827 3.633 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr14_+_75455957 3.525 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr17_+_27556641 3.440 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr14_-_48667508 3.143 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr3_+_94377432 3.123 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr18_-_66860458 3.079 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr18_-_13972617 3.028 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr14_-_40893222 3.018 ENSMUST00000096000.3
 Sh2d4b
SH2 domain containing 4B
chr3_-_141982224 2.995 ENSMUST00000029948.8
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr2_+_61804453 2.934 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr10_-_64090241 2.846 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.9 GO:0006284 base-excision repair(GO:0006284)
0.9 8.0 GO:0010587 miRNA catabolic process(GO:0010587)
0.5 6.7 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.7 5.9 GO:0072615 interleukin-17 secretion(GO:0072615)
0.4 5.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.9 4.6 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.1 4.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 4.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.0 3.9 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.7 3.9 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 3.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.3 3.6 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 3.6 GO:0043488 regulation of mRNA stability(GO:0043488)
0.7 3.5 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 3.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.8 3.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 3.1 GO:0002024 diet induced thermogenesis(GO:0002024)
0.7 3.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.6 2.9 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.5 2.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 10.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.7 4.2 GO:0031262 Ndc80 complex(GO:0031262)
0.8 3.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 3.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 3.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 2.8 GO:0042788 polysomal ribosome(GO:0042788)
0.4 2.6 GO:0045179 apical cortex(GO:0045179)
0.0 2.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 2.3 GO:0044305 calyx of Held(GO:0044305)
0.3 2.1 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.2 2.1 GO:0002177 manchette(GO:0002177)
0.2 2.1 GO:0070852 cell body fiber(GO:0070852)
0.6 1.9 GO:1990423 RZZ complex(GO:1990423)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.0 1.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.3 1.3 GO:0008623 CHRAC(GO:0008623)
0.3 1.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 1.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 11.0 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.2 7.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.5 5.9 GO:0008142 oxysterol binding(GO:0008142)
0.0 5.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 4.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.0 GO:0001047 core promoter binding(GO:0001047)
1.3 3.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.6 3.9 GO:0000150 recombinase activity(GO:0000150)
0.0 3.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 3.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
1.0 3.1 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.3 2.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 2.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 2.8 GO:0017091 AU-rich element binding(GO:0017091)
0.9 2.7 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 2.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 2.3 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.0 2.3 GO:0005496 steroid binding(GO:0005496)
0.7 2.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.3 1.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 5.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.0 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 0.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.8 PID_P73PATHWAY p73 transcription factor network
0.0 0.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.6 PID_P53_REGULATION_PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 10.8 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 9.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 7.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 3.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 3.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 3.4 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.3 2.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.3 2.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 2.5 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT Genes involved in Aquaporin-mediated transport
0.7 2.1 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.2 1.7 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.2 1.7 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.4 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 1.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins