Motif ID: Prox1

Z-value: 0.538


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.315.1e-02Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 77 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_60144682 2.448 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr5_-_37824580 1.457 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr1_-_169747634 1.321 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr15_-_80014808 1.223 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr4_-_131821516 1.003 ENSMUST00000097860.2
 Ptpru
protein tyrosine phosphatase, receptor type, U
chr4_+_130913120 0.904 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr6_+_58640536 0.876 ENSMUST00000145161.1
ENSMUST00000114294.1
 Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr4_+_130913264 0.829 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr12_-_83487708 0.724 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr18_-_20682963 0.685 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chr2_-_92459709 0.645 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1

chr4_+_140701466 0.637 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr5_+_139252343 0.636 ENSMUST00000130326.1
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr9_+_104569671 0.621 ENSMUST00000057742.8
 Cpne4
copine IV
chr19_+_41911851 0.605 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr17_+_27839974 0.541 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr9_-_106247730 0.524 ENSMUST00000112524.2
ENSMUST00000074082.6
 Alas1

aminolevulinic acid synthase 1

chr6_-_131388417 0.497 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr19_-_15924560 0.486 ENSMUST00000162053.1
 Psat1
phosphoserine aminotransferase 1
chr7_-_127448993 0.474 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.5 1.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 1.3 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.4 1.2 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 1.0 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 1.0 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 1.0 GO:0034394 protein localization to cell surface(GO:0034394)
0.3 0.9 GO:0019389 urate transport(GO:0015747) glucuronoside metabolic process(GO:0019389) negative regulation of intestinal absorption(GO:1904479)
0.0 0.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.2 0.6 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.6 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 0.6 GO:0030259 lipid glycosylation(GO:0030259)
0.2 0.5 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.4 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 0.4 GO:0042711 maternal behavior(GO:0042711)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.7 GO:0071565 nBAF complex(GO:0071565)
0.0 0.6 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.5 GO:0000243 commitment complex(GO:0000243)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.0 1.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 1.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 0.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.2 0.6 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.5 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483)
0.1 0.4 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 0.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 1.0 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.0 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.0 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 0.9 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)