Motif ID: Rad21_Smc3
Z-value: 0.927
Transcription factors associated with Rad21_Smc3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rad21 | ENSMUSG00000022314.9 | Rad21 |
| Smc3 | ENSMUSG00000024974.10 | Smc3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rad21 | mm10_v2_chr15_-_51991679_51991760 | -0.45 | 3.4e-03 | Click! |
| Smc3 | mm10_v2_chr19_+_53600377_53600435 | -0.10 | 5.4e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 181 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.7 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
| 0.0 | 4.4 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.0 | 3.8 | GO:0051480 | regulation of cytosolic calcium ion concentration(GO:0051480) |
| 1.2 | 3.5 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625) |
| 0.4 | 3.5 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) |
| 0.6 | 3.4 | GO:0032439 | endosome localization(GO:0032439) |
| 0.6 | 3.0 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.9 | 2.7 | GO:1902071 | positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
| 0.9 | 2.6 | GO:0002636 | positive regulation of germinal center formation(GO:0002636) |
| 0.0 | 2.6 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.6 | 2.5 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.5 | 2.5 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.8 | 2.3 | GO:0035799 | ureter maturation(GO:0035799) |
| 0.2 | 2.2 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.3 | 2.0 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.2 | 2.0 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 1.9 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 1.9 | GO:1903214 | regulation of protein targeting to mitochondrion(GO:1903214) |
| 0.4 | 1.8 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.2 | 1.8 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 87 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.8 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 3.4 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.6 | 3.3 | GO:0045179 | apical cortex(GO:0045179) |
| 0.9 | 2.8 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.2 | 2.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.4 | 2.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 2.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.4 | 2.4 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.3 | 2.1 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 2.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1.8 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 1.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 1.7 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 1.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 1.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 1.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 1.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 1.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.3 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 114 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 1.2 | 3.5 | GO:0004454 | ketohexokinase activity(GO:0004454) |
| 0.0 | 3.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 3.2 | GO:0044390 | ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.2 | 2.9 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) |
| 0.1 | 2.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 2.8 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.2 | 2.6 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.2 | 2.4 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.0 | 2.4 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.5 | 2.3 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.2 | 2.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.1 | 2.1 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.1 | 2.1 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 2.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.4 | 1.8 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 1.8 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 1.6 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 1.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 20 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.9 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 2.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 2.6 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.6 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.4 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.3 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.3 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.0 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.8 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.7 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.6 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.6 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.4 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.0 | 0.4 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.4 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.4 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.2 | PID_IL5_PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 34 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.1 | 3.8 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 2.5 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 2.4 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 2.1 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 2.1 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.1 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 2.0 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 2.0 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 1.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.7 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 1.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.2 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.2 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.1 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.9 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.7 | REACTOME_FRS2_MEDIATED_CASCADE | Genes involved in FRS2-mediated cascade |
| 0.0 | 0.7 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
|
|
|