Motif ID: Rara

Z-value: 0.667


Transcription factors associated with Rara:

Gene SymbolEntrez IDGene Name
Rara ENSMUSG00000037992.10 Rara

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raramm10_v2_chr11_+_98927785_989278180.481.5e-03Click!


Activity profile for motif Rara.

activity profile for motif Rara


Sorted Z-values histogram for motif Rara

Sorted Z-values for motif Rara



Network of associatons between targets according to the STRING database.



First level regulatory network of Rara

PNG image of the network

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Top targets:


Showing 1 to 20 of 68 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_94875600 4.662 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr11_+_98960412 3.838 ENSMUST00000107473.2
 Rara
retinoic acid receptor, alpha
chr4_-_141599835 3.485 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr2_+_169633517 3.079 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr3_-_54915867 2.582 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr12_+_87026564 1.656 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr1_-_175692624 1.462 ENSMUST00000027809.7
 Opn3
opsin 3
chr17_+_34593388 1.454 ENSMUST00000174532.1
 Pbx2
pre B cell leukemia homeobox 2
chr4_+_150853919 1.439 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr17_-_56133817 1.433 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr4_+_32238950 1.401 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr4_-_46991842 1.279 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr6_+_91157373 1.238 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr14_-_16575456 1.131 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr5_+_135806859 1.048 ENSMUST00000126232.1
 Srrm3
serine/arginine repetitive matrix 3
chr4_+_32238713 0.993 ENSMUST00000108180.2
 Bach2
BTB and CNC homology 2
chr10_-_89257790 0.958 ENSMUST00000045601.7
 Ano4
anoctamin 4
chr6_+_30723541 0.911 ENSMUST00000115127.1
 Mest
mesoderm specific transcript
chr12_-_108893197 0.906 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr7_-_17056669 0.898 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.4 GO:0021979 hypothalamus cell differentiation(GO:0021979)
1.3 3.8 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.2 3.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.5 1.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.5 1.4 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 1.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.2 GO:0014003 oligodendrocyte development(GO:0014003)
0.4 1.1 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.2 1.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.3 1.0 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.3 0.9 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.9 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.9 GO:0010883 regulation of lipid storage(GO:0010883)
0.1 0.8 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 0.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.8 GO:0060484 male sex determination(GO:0030238) lung-associated mesenchyme development(GO:0060484)
0.2 0.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0001650 fibrillar center(GO:0001650)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.3 1.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.8 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.2 3.5 GO:0031005 filamin binding(GO:0031005)
0.0 3.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 1.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.5 1.5 GO:0009881 photoreceptor activity(GO:0009881)
0.0 1.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 1.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.3 0.9 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.8 GO:0005158 insulin receptor binding(GO:0005158)
0.2 0.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 1.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.9 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 0.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.8 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression