Motif ID: Rbpj

Z-value: 1.008


Transcription factors associated with Rbpj:

Gene SymbolEntrez IDGene Name
Rbpj ENSMUSG00000039191.6 Rbpj

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rbpjmm10_v2_chr5_+_53590215_53590351-0.019.6e-01Click!


Activity profile for motif Rbpj.

activity profile for motif Rbpj


Sorted Z-values histogram for motif Rbpj

Sorted Z-values for motif Rbpj



Network of associatons between targets according to the STRING database.



First level regulatory network of Rbpj

PNG image of the network

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Top targets:


Showing 1 to 20 of 145 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 16.242 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_+_78324200 13.195 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr10_-_30842765 8.447 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr4_+_156203292 5.896 ENSMUST00000105140.2
 AW011738
expressed sequence AW011738
chr6_-_5298455 5.008 ENSMUST00000057792.8
 Pon2
paraoxonase 2
chr2_+_59612034 4.614 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr11_-_102579461 4.570 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr2_+_37776229 4.299 ENSMUST00000050372.7
 Crb2
crumbs homolog 2 (Drosophila)
chr11_+_101627942 3.649 ENSMUST00000010506.3
 Rdm1
RAD52 motif 1
chr2_+_105668935 3.384 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr2_+_105668888 3.298 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr5_+_136919137 3.295 ENSMUST00000181045.1
 4933404O12Rik
RIKEN cDNA 4933404O12 gene
chrX_+_139684980 3.284 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr19_+_53140430 3.155 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr12_-_80260091 2.678 ENSMUST00000167327.1
 Actn1
actinin, alpha 1
chr5_-_77115145 2.545 ENSMUST00000081964.5
 Hopx
HOP homeobox
chr6_+_29694204 2.473 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr9_-_26806384 2.277 ENSMUST00000162702.1
ENSMUST00000040398.7
ENSMUST00000066560.6
 Glb1l2


galactosidase, beta 1-like 2


chr12_-_80260356 2.206 ENSMUST00000021554.8
 Actn1
actinin, alpha 1
chr2_-_26140468 2.031 ENSMUST00000133808.1
 C330006A16Rik
RIKEN cDNA C330006A16 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 16.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.3 13.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
2.8 8.4 GO:0003195 tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
1.3 6.7 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.3 5.1 GO:0051639 actin filament network formation(GO:0051639)
0.3 5.0 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 5.0 GO:0009636 response to toxic substance(GO:0009636)
0.2 4.6 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 3.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 3.2 GO:0042493 response to drug(GO:0042493)
0.9 2.7 GO:0014028 notochord formation(GO:0014028)
0.4 2.5 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 2.5 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 2.5 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 2.3 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.2 2.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 2.0 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.2 2.0 GO:0019985 translesion synthesis(GO:0019985)
0.6 1.8 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.8 GO:0030903 notochord development(GO:0030903)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.2 GO:0030424 axon(GO:0030424)
0.4 8.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 6.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 6.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 5.5 GO:0005903 brush border(GO:0005903)
1.2 4.9 GO:0032127 dense core granule membrane(GO:0032127)
0.0 4.3 GO:0016324 apical plasma membrane(GO:0016324)
0.3 2.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.5 GO:0005871 kinesin complex(GO:0005871)
0.0 2.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.1 GO:0042555 MCM complex(GO:0042555)
0.3 2.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 2.0 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.6 1.8 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 1.6 GO:0043197 dendritic spine(GO:0043197)
0.1 1.4 GO:0043218 compact myelin(GO:0043218)
0.3 1.3 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.3 1.2 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 1.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.2 13.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
2.8 8.4 GO:0035939 microsatellite binding(GO:0035939)
0.4 6.7 GO:0003680 AT DNA binding(GO:0003680)
0.0 5.2 GO:0019903 protein phosphatase binding(GO:0019903)
1.3 5.0 GO:0004064 arylesterase activity(GO:0004064)
0.3 4.9 GO:0017166 vinculin binding(GO:0017166)
0.1 4.4 GO:0005080 protein kinase C binding(GO:0005080)
0.9 4.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 3.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.5 GO:0003777 microtubule motor activity(GO:0003777)
0.5 2.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 2.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.4 1.6 GO:0038025 reelin receptor activity(GO:0038025)
0.5 1.5 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.2 1.5 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 1.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.0 PID_CDC42_PATHWAY CDC42 signaling events
0.2 9.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 4.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.1 0.9 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.6 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 24.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 13.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.5 6.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.6 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 1.5 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 1.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.1 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.0 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.8 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA