Motif ID: Rela_Rel_Nfkb1

Z-value: 1.290

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb1mm10_v2_chr3_-_135608221_1356082900.453.4e-03Click!
Relamm10_v2_chr19_+_5637475_5637486-0.221.7e-01Click!


Activity profile for motif Rela_Rel_Nfkb1.

activity profile for motif Rela_Rel_Nfkb1


Sorted Z-values histogram for motif Rela_Rel_Nfkb1

Sorted Z-values for motif Rela_Rel_Nfkb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_165234689 18.227 ENSMUST00000065438.6
 Cdh22
cadherin 22
chr1_+_74791516 9.232 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr14_-_70642268 8.000 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr6_+_4755327 7.320 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr8_-_61902669 7.003 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr18_+_4994600 5.236 ENSMUST00000140448.1
 Svil
supervillin
chr7_-_25788635 4.792 ENSMUST00000002677.4
ENSMUST00000085948.4
 Axl

AXL receptor tyrosine kinase

chr7_-_103843154 4.741 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr6_+_48841476 4.129 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 4.017 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr12_+_79029150 3.678 ENSMUST00000039928.5
 Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr19_-_58454580 3.570 ENSMUST00000129100.1
ENSMUST00000123957.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr19_-_58455161 3.462 ENSMUST00000135730.1
ENSMUST00000152507.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr17_-_35000848 3.390 ENSMUST00000166828.3
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr2_-_156839790 3.335 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
 Gm14230


predicted gene 14230


chr12_+_109747903 3.215 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr5_+_92925400 3.187 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr5_+_114568016 3.102 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr19_-_58454435 3.084 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr12_-_91746020 3.057 ENSMUST00000166967.1
 Ston2
stonin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 16.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
2.0 13.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.8 11.5 GO:0048733 sebaceous gland development(GO:0048733)
1.0 9.7 GO:0008063 Toll signaling pathway(GO:0008063)
0.5 7.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 7.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 5.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
1.6 4.8 GO:0097350 neutrophil clearance(GO:0097350)
0.9 4.7 GO:0015671 oxygen transport(GO:0015671)
0.0 4.5 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.6 4.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 4.1 GO:0048536 spleen development(GO:0048536)
0.3 4.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 4.0 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 4.0 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
1.1 3.2 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.3 3.2 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.4 3.1 GO:0007296 vitellogenesis(GO:0007296)
0.7 3.0 GO:0030091 protein repair(GO:0030091)
0.2 3.0 GO:0022027 interkinetic nuclear migration(GO:0022027)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.3 GO:0031225 anchored component of membrane(GO:0031225)
0.6 8.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 7.5 GO:0043034 costamere(GO:0043034)
0.2 7.2 GO:0002102 podosome(GO:0002102)
0.1 5.0 GO:0005882 intermediate filament(GO:0005882)
0.1 5.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 4.8 GO:0043296 apical junction complex(GO:0043296)
0.6 4.7 GO:0005833 hemoglobin complex(GO:0005833)
0.0 4.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 4.0 GO:0000922 spindle pole(GO:0000922)
0.7 3.9 GO:0098536 deuterosome(GO:0098536)
0.0 3.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.5 3.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 3.4 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.6 3.2 GO:0031523 Myb complex(GO:0031523)
0.0 2.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.9 2.7 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 2.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.8 2.5 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 2.5 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.7 GO:0005178 integrin binding(GO:0005178)
0.0 11.7 GO:0005509 calcium ion binding(GO:0005509)
0.1 10.6 GO:0051015 actin filament binding(GO:0051015)
0.8 9.7 GO:0031996 thioesterase binding(GO:0031996)
0.2 9.4 GO:0005109 frizzled binding(GO:0005109)
2.7 8.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 4.8 GO:0032036 myosin heavy chain binding(GO:0032036)
1.2 4.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 4.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 4.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.4 4.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 3.7 GO:0019215 intermediate filament binding(GO:0019215)
0.8 3.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.3 3.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 3.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.7 2.9 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.1 2.9 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.5 2.7 GO:0035240 dopamine binding(GO:0035240)
0.6 2.6 GO:1990254 keratin filament binding(GO:1990254)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 10.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 9.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 9.2 PID_FGF_PATHWAY FGF signaling pathway
0.1 7.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 6.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 5.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 5.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.9 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 4.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 4.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 3.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 3.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 3.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 2.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 2.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 2.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.2 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 2.1 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 9.8 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 9.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 9.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.9 8.0 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 4.8 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 4.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 3.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 3.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 2.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 2.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 2.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 2.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.3 2.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.9 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.9 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.9 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events