Motif ID: Relb

Z-value: 0.619


Transcription factors associated with Relb:

Gene SymbolEntrez IDGene Name
Relb ENSMUSG00000002983.10 Relb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Relbmm10_v2_chr7_-_19629355_196294510.524.3e-04Click!


Activity profile for motif Relb.

activity profile for motif Relb


Sorted Z-values histogram for motif Relb

Sorted Z-values for motif Relb



Network of associatons between targets according to the STRING database.



First level regulatory network of Relb

PNG image of the network

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Top targets:


Showing 1 to 20 of 76 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 4.828 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr3_-_107760221 4.161 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr9_+_64385626 3.718 ENSMUST00000093829.2
ENSMUST00000118485.1
ENSMUST00000164113.1
 Megf11


multiple EGF-like-domains 11


chr9_+_64385675 2.721 ENSMUST00000068967.4
 Megf11
multiple EGF-like-domains 11
chr2_-_5714490 2.457 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr7_+_99535652 1.873 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr3_-_9610074 1.702 ENSMUST00000041124.7
 Zfp704
zinc finger protein 704
chr1_+_15287259 1.702 ENSMUST00000175681.1
 Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr2_-_5063996 1.679 ENSMUST00000114996.1
 Optn
optineurin
chr7_+_99535439 1.669 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr7_+_43463145 1.500 ENSMUST00000107977.1
 Vsig10l
ZV-set and immunoglobulin domain containing 10 like
chr2_-_5063932 1.443 ENSMUST00000027986.4
 Optn
optineurin
chr15_-_79164477 1.408 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chrX_+_163909132 1.400 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr13_+_83732438 1.341 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr15_-_98677451 1.269 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr8_+_46739745 1.268 ENSMUST00000034041.7
 Irf2
interferon regulatory factor 2
chr18_+_37484955 1.230 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr2_+_10153563 1.195 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5
chr18_+_36559972 1.130 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.4 GO:0010842 retina layer formation(GO:0010842)
0.1 4.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.4 4.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.6 3.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.8 3.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.4 2.5 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 2.4 GO:0060612 adipose tissue development(GO:0060612)
0.3 1.4 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.1 1.3 GO:0016322 neuron remodeling(GO:0016322)
0.0 1.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.4 1.1 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.2 1.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.2 1.0 GO:0009597 detection of virus(GO:0009597)
0.2 1.0 GO:0007256 activation of JNKK activity(GO:0007256)
0.2 1.0 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.1 0.9 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.2 0.8 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.1 0.7 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.7 GO:0048149 behavioral response to ethanol(GO:0048149)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0042581 specific granule(GO:0042581)
1.4 4.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 3.5 GO:0031143 pseudopodium(GO:0031143)
0.0 3.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 1.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 1.4 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.0 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 0.6 GO:0033010 paranodal junction(GO:0033010)
0.1 0.5 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0045296 cadherin binding(GO:0045296)
0.0 4.2 GO:0005125 cytokine activity(GO:0005125)
1.2 3.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.3 3.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 2.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.4 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 1.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 1.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.8 GO:0005131 growth hormone receptor binding(GO:0005131)
0.2 0.7 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 0.6 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.0 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.5 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 4.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 1.8 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.2 0.9 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.8 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 2.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.3 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.7 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions