Motif ID: Rfx2_Rfx7

Z-value: 1.321

Transcription factors associated with Rfx2_Rfx7:

Gene SymbolEntrez IDGene Name
Rfx2 ENSMUSG00000024206.8 Rfx2
Rfx7 ENSMUSG00000037674.9 Rfx7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx2mm10_v2_chr17_-_56830916_56831008-0.409.4e-03Click!
Rfx7mm10_v2_chr9_+_72532214_725322710.057.5e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx2_Rfx7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_156562141 8.352 ENSMUST00000175773.1
Negr1
neuronal growth regulator 1
chr3_+_156561792 5.788 ENSMUST00000074015.4
Negr1
neuronal growth regulator 1
chr14_-_37098211 5.099 ENSMUST00000022337.9
Cdhr1
cadherin-related family member 1
chr8_+_39005880 5.030 ENSMUST00000169034.1
Tusc3
tumor suppressor candidate 3
chr2_-_28466266 4.748 ENSMUST00000127683.1
ENSMUST00000086370.4
1700007K13Rik

RIKEN cDNA 1700007K13 gene

chr8_+_39005827 4.637 ENSMUST00000167992.1
Tusc3
tumor suppressor candidate 3
chr3_+_156561950 4.449 ENSMUST00000041425.5
ENSMUST00000106065.1
Negr1

neuronal growth regulator 1

chr7_-_31051431 4.106 ENSMUST00000073892.4
Fxyd7
FXYD domain-containing ion transport regulator 7
chr5_-_128953303 4.093 ENSMUST00000111346.1
Rimbp2
RIMS binding protein 2
chrX_+_52791179 3.926 ENSMUST00000101588.1
Ccdc160
coiled-coil domain containing 160
chr5_+_27261916 3.599 ENSMUST00000101471.3
Dpp6
dipeptidylpeptidase 6
chr11_-_23633621 3.447 ENSMUST00000180260.1
ENSMUST00000141353.1
ENSMUST00000131612.1
ENSMUST00000109532.2
0610010F05Rik



RIKEN cDNA 0610010F05 gene



chr4_+_117096049 3.354 ENSMUST00000030443.5
Ptch2
patched homolog 2
chr18_+_75820174 3.317 ENSMUST00000058997.7
Zbtb7c
zinc finger and BTB domain containing 7C
chr3_+_82358056 3.124 ENSMUST00000091014.4
Map9
microtubule-associated protein 9
chr13_+_112993868 3.041 ENSMUST00000092089.4
Mcidas
multiciliate differentiation and DNA synthesis associated cell cycle protein
chr7_+_4922251 3.018 ENSMUST00000047309.5
Nat14
N-acetyltransferase 14
chr11_+_100545607 3.009 ENSMUST00000092684.5
ENSMUST00000006976.7
Ttc25

tetratricopeptide repeat domain 25

chr7_+_16959714 2.983 ENSMUST00000038163.6
Pnmal1
PNMA-like 1
chr8_-_54724317 2.943 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
Wdr17


WD repeat domain 17



Gene overrepresentation in biological_process category:

Showing 1 to 20 of 178 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.7 GO:0007631 feeding behavior(GO:0007631)
0.5 9.7 GO:0015693 magnesium ion transport(GO:0015693)
0.1 5.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.2 4.4 GO:0003351 epithelial cilium movement(GO:0003351)
0.1 4.2 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 3.7 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 3.6 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.8 3.4 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 3.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 3.3 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.8 3.2 GO:0046898 response to cycloheximide(GO:0046898)
0.6 3.1 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.5 2.7 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 2.7 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.6 2.4 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 2.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.3 GO:0000338 protein deneddylation(GO:0000338)
0.4 2.2 GO:1904717 positive regulation of synapse structural plasticity(GO:0051835) regulation of AMPA glutamate receptor clustering(GO:1904717)
0.2 2.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.2 2.2 GO:0070286 axonemal dynein complex assembly(GO:0070286)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.4 GO:0031225 anchored component of membrane(GO:0031225)
0.6 9.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 6.1 GO:0060170 ciliary membrane(GO:0060170)
0.4 5.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 4.0 GO:0035371 microtubule plus-end(GO:0035371)
0.2 3.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 3.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 3.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.5 3.1 GO:0000235 astral microtubule(GO:0000235)
0.1 3.1 GO:0008180 COP9 signalosome(GO:0008180)
0.3 3.0 GO:0036157 outer dynein arm(GO:0036157)
0.0 2.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.4 GO:0030496 midbody(GO:0030496)
0.5 2.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 2.0 GO:0043209 myelin sheath(GO:0043209)
0.6 1.9 GO:0036156 inner dynein arm(GO:0036156)
0.3 1.9 GO:0070695 FHF complex(GO:0070695)
0.0 1.9 GO:0001726 ruffle(GO:0001726)
0.0 1.7 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 9.7 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 7.6 GO:0003924 GTPase activity(GO:0003924)
0.1 5.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 3.9 GO:0030276 clathrin binding(GO:0030276)
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)
0.1 3.6 GO:0015459 potassium channel regulator activity(GO:0015459)
1.1 3.4 GO:0005119 smoothened binding(GO:0005119)
0.4 3.2 GO:0051434 BH3 domain binding(GO:0051434)
0.2 3.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 2.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 2.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 2.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 2.7 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 2.5 GO:0051015 actin filament binding(GO:0051015)
0.0 2.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.6 2.3 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.5 2.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 2.2 GO:0031005 filamin binding(GO:0031005)
0.0 2.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 2.2 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 3.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.7 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 6.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 3.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 2.4 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.0 1.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.8 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 1.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.2 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.0 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.8 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.7 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.6 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane