Motif ID: Rhox4e_Rhox6_Vax2

Z-value: 1.084

Transcription factors associated with Rhox4e_Rhox6_Vax2:

Gene SymbolEntrez IDGene Name
Rhox4e ENSMUSG00000071770.4 Rhox4e
Rhox6 ENSMUSG00000006200.3 Rhox6
Vax2 ENSMUSG00000034777.1 Vax2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vax2mm10_v2_chr6_+_83711232_83711288-0.241.4e-01Click!


Activity profile for motif Rhox4e_Rhox6_Vax2.

activity profile for motif Rhox4e_Rhox6_Vax2


Sorted Z-values histogram for motif Rhox4e_Rhox6_Vax2

Sorted Z-values for motif Rhox4e_Rhox6_Vax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 23.325 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_60893430 8.367 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr8_+_45658666 5.889 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 5.735 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr4_+_15881255 4.803 ENSMUST00000029876.1
 Calb1
calbindin 1
chr15_-_67113909 4.638 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_-_89933290 4.559 ENSMUST00000036954.7
 Gbx2
gastrulation brain homeobox 2
chr3_+_55782500 4.499 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr13_-_102906046 3.908 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr7_-_25005895 3.824 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr9_+_53771499 3.486 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr13_-_102905740 3.357 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr12_-_112511136 3.352 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr9_+_102720287 3.031 ENSMUST00000130602.1
 Amotl2
angiomotin-like 2
chr16_-_42340595 2.985 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr14_+_5517172 2.940 ENSMUST00000178220.1
 Gm3488
predicted gene, 3488
chr14_+_5164535 2.940 ENSMUST00000179659.1
 Gm3317
predicted gene 3317
chr3_-_86548268 2.849 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr8_+_45507768 2.676 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr12_+_109545390 2.636 ENSMUST00000146701.1
 Meg3
maternally expressed 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 23.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 14.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 8.4 GO:0007530 sex determination(GO:0007530)
0.0 8.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
1.0 4.8 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.7 4.6 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1 4.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 3.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.4 3.8 GO:0036376 sodium ion export from cell(GO:0036376)
0.3 3.0 GO:0016198 axon choice point recognition(GO:0016198)
0.1 3.0 GO:0035329 hippo signaling(GO:0035329)
0.1 2.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 2.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 2.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.4 GO:0000910 cytokinesis(GO:0000910)
0.1 2.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 2.0 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.1 1.9 GO:0003334 keratinocyte development(GO:0003334)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 4.8 GO:0043195 terminal bouton(GO:0043195)
0.0 3.9 GO:0000792 heterochromatin(GO:0000792)
0.5 3.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 3.4 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.0 GO:0031527 filopodium membrane(GO:0031527)
0.2 2.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.2 2.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 2.0 GO:0098536 deuterosome(GO:0098536)
0.0 2.0 GO:0043034 costamere(GO:0043034)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.0 GO:0070382 exocytic vesicle(GO:0070382)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.2 1.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 1.2 GO:0097413 Lewy body(GO:0097413)
0.4 1.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 11.2 GO:0019904 protein domain specific binding(GO:0019904)
0.2 8.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 7.3 GO:0000287 magnesium ion binding(GO:0000287)
1.2 4.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 4.6 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 4.6 GO:0019842 vitamin binding(GO:0019842)
0.4 3.8 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 3.4 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 3.3 GO:0003924 GTPase activity(GO:0003924)
0.4 3.0 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 2.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 2.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.7 GO:0051015 actin filament binding(GO:0051015)
0.1 1.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.2 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 3.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.3 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta