Motif ID: Rora

Z-value: 0.921


Transcription factors associated with Rora:

Gene SymbolEntrez IDGene Name
Rora ENSMUSG00000032238.11 Rora

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Roramm10_v2_chr9_+_68653761_686537860.261.0e-01Click!


Activity profile for motif Rora.

activity profile for motif Rora


Sorted Z-values histogram for motif Rora

Sorted Z-values for motif Rora



Network of associatons between targets according to the STRING database.



First level regulatory network of Rora

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 5.472 ENSMUST00000168589.1
 Sla
src-like adaptor
chr16_+_11406618 4.179 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr9_-_75597643 4.054 ENSMUST00000164100.1
 Tmod2
tropomodulin 2
chr1_+_159737510 3.668 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_-_106696819 3.660 ENSMUST00000127434.1
ENSMUST00000112696.1
ENSMUST00000112698.1
 Zfp644


zinc finger protein 644


chr3_-_107517321 3.571 ENSMUST00000166892.1
 Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr2_+_4300462 3.493 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr7_-_12422751 3.435 ENSMUST00000080348.5
 Zfp551
zinc fingr protein 551
chr11_+_42419729 3.397 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr5_+_37028329 3.200 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr10_-_8518801 3.137 ENSMUST00000061601.7
 Ust
uronyl-2-sulfotransferase
chr5_-_113015473 3.120 ENSMUST00000065167.4
 Adrbk2
adrenergic receptor kinase, beta 2
chr16_+_10545390 3.106 ENSMUST00000115827.1
ENSMUST00000038145.6
ENSMUST00000150894.1
 Clec16a


C-type lectin domain family 16, member A


chr2_-_130839683 3.021 ENSMUST00000119422.1
 4930402H24Rik
RIKEN cDNA 4930402H24 gene
chr2_-_5676046 2.980 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr19_-_37207293 2.943 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr5_+_19227046 2.935 ENSMUST00000088516.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_-_106696530 2.906 ENSMUST00000137285.1
ENSMUST00000124263.1
ENSMUST00000112695.1
ENSMUST00000155495.1
ENSMUST00000135108.1
 Zfp644




zinc finger protein 644




chr2_+_29965560 2.875 ENSMUST00000113717.1
ENSMUST00000113719.2
ENSMUST00000100225.2
ENSMUST00000113741.1
ENSMUST00000095083.4
ENSMUST00000046257.7
 Sptan1





spectrin alpha, non-erythrocytic 1





chr17_-_43667015 2.846 ENSMUST00000024705.4
 Slc25a27
solute carrier family 25, member 27

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.8 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 5.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.8 4.2 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.7 4.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.9 3.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.7 3.6 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 3.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.4 3.4 GO:0071420 cellular response to histamine(GO:0071420)
0.2 3.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.5 3.1 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.0 3.1 GO:0030010 establishment of cell polarity(GO:0030010)
0.4 3.0 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.4 2.9 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 2.9 GO:0051693 actin filament capping(GO:0051693)
0.7 2.8 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.3 2.7 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 2.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.9 2.6 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.4 2.5 GO:0035902 response to immobilization stress(GO:0035902)
0.8 2.4 GO:0071929 alpha-tubulin acetylation(GO:0071929)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 GO:0008021 synaptic vesicle(GO:0008021)
0.3 6.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 6.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 5.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 5.0 GO:0030426 growth cone(GO:0030426)
0.0 4.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
1.2 3.7 GO:0072534 perineuronal net(GO:0072534)
0.2 3.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 3.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.6 2.9 GO:0032437 cuticular plate(GO:0032437)
0.4 2.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 2.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.8 GO:0045177 apical part of cell(GO:0045177)
0.2 2.5 GO:0042788 polysomal ribosome(GO:0042788)
0.3 2.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 2.3 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.1 2.1 GO:0043194 axon initial segment(GO:0043194)
0.2 2.0 GO:0046930 pore complex(GO:0046930)
0.1 1.8 GO:0010369 chromocenter(GO:0010369)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 6.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 5.6 GO:0030674 protein binding, bridging(GO:0030674)
0.1 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 4.1 GO:0005523 tropomyosin binding(GO:0005523)
0.1 4.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 3.9 GO:0030507 spectrin binding(GO:0030507)
0.0 3.8 GO:0005096 GTPase activator activity(GO:0005096)
0.2 3.7 GO:0046625 sphingolipid binding(GO:0046625)
0.2 3.6 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.8 3.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 3.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 3.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.1 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 3.0 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.5 2.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 2.9 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.2 2.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 2.6 GO:0019841 retinol binding(GO:0019841)
0.1 2.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 3.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.2 2.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 1.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 1.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 0.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 4.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 3.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 3.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.1 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.2 3.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.4 2.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 2.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.2 2.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 2.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.2 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 2.0 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.6 1.9 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.6 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.0 1.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling