Motif ID: Rreb1

Z-value: 0.863


Transcription factors associated with Rreb1:

Gene SymbolEntrez IDGene Name
Rreb1 ENSMUSG00000039087.10 Rreb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rreb1mm10_v2_chr13_+_37826225_378263150.038.6e-01Click!


Activity profile for motif Rreb1.

activity profile for motif Rreb1


Sorted Z-values histogram for motif Rreb1

Sorted Z-values for motif Rreb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rreb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_83791939 5.295 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr17_+_35076902 5.183 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr11_-_69369377 4.469 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr13_+_43615710 3.670 ENSMUST00000059986.2
 Rnf182
ring finger protein 182
chr8_+_57455898 3.535 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr11_+_67586675 3.418 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr11_+_67586520 3.355 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr17_+_35077080 3.328 ENSMUST00000172959.1
 Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr5_+_37047464 3.029 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr5_-_122002340 2.965 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr13_+_109632760 2.572 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr2_-_33371400 2.490 ENSMUST00000113164.1
ENSMUST00000091039.2
ENSMUST00000042615.6
 Ralgps1


Ral GEF with PH domain and SH3 binding motif 1


chr12_+_81026800 2.422 ENSMUST00000110347.2
ENSMUST00000021564.4
ENSMUST00000129362.1
 Smoc1


SPARC related modular calcium binding 1


chr3_-_73056943 2.310 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr2_-_33371486 2.275 ENSMUST00000113165.1
 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr5_-_89883321 2.241 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr16_-_67620880 2.197 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr8_-_11008458 2.196 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr14_-_34201604 2.158 ENSMUST00000096019.2
 Gprin2
G protein regulated inducer of neurite outgrowth 2
chr12_+_12262139 2.145 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.3 7.1 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
1.0 4.8 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 4.5 GO:0007098 centrosome cycle(GO:0007098)
0.1 4.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.6 3.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 3.8 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 3.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.9 2.8 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.4 2.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 2.8 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.1 2.7 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.9 2.6 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 2.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.4 GO:0061512 protein localization to cilium(GO:0061512)
0.4 2.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 2.2 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 2.2 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.4 2.1 GO:0034436 glycoprotein transport(GO:0034436)
0.3 2.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 5.0 GO:0005884 actin filament(GO:0005884)
0.1 4.2 GO:0032809 neuronal cell body membrane(GO:0032809)
1.0 3.8 GO:1990769 proximal neuron projection(GO:1990769)
0.0 3.4 GO:0044306 neuron projection terminus(GO:0044306)
1.1 3.2 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 3.1 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 3.1 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 3.0 GO:0000139 Golgi membrane(GO:0000139)
0.2 2.8 GO:0044327 dendritic spine head(GO:0044327)
0.5 2.6 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 2.3 GO:0043235 receptor complex(GO:0043235)
0.2 2.2 GO:0016342 catenin complex(GO:0016342)
0.2 2.1 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 1.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.6 GO:0009986 cell surface(GO:0009986)
0.1 1.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 8.5 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.8 4.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 4.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.2 GO:0051015 actin filament binding(GO:0051015)
0.1 4.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 3.7 GO:0008017 microtubule binding(GO:0008017)
0.1 3.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 3.0 GO:0050811 GABA receptor binding(GO:0050811)
0.7 2.8 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 2.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 2.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 2.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 2.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 2.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 2.2 GO:0015485 cholesterol binding(GO:0015485)
0.0 2.2 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.7 2.1 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.2 2.1 GO:0050897 cobalt ion binding(GO:0050897)
0.1 1.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.4 1.6 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 3.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 3.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.2 PID_EPO_PATHWAY EPO signaling pathway
0.1 2.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.4 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.1 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.9 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 0.7 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 0.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID_S1P_S1P1_PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 4.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.7 2.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.9 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.7 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 1.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 1.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.0 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 0.9 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling