Motif ID: Runx1

Z-value: 0.856


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 9.628 ENSMUST00000168589.1
 Sla
src-like adaptor
chr16_+_42907563 8.687 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr17_+_3397189 6.239 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr3_-_107760221 5.392 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr8_-_11008458 5.366 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr13_+_76579670 3.698 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr16_+_43510267 3.449 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chrX_+_151344171 3.336 ENSMUST00000073364.5
 Fam120c
family with sequence similarity 120, member C
chr13_+_49608030 3.324 ENSMUST00000021822.5
 Ogn
osteoglycin
chr12_-_25096080 3.114 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr15_-_76090013 3.102 ENSMUST00000019516.4
 Nrbp2
nuclear receptor binding protein 2
chr12_-_34528844 2.779 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chrX_+_159697308 2.725 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr17_+_75178797 2.499 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr15_-_102722120 2.341 ENSMUST00000171838.1
 Calcoco1
calcium binding and coiled coil domain 1
chr2_+_37516618 2.310 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr2_-_52335134 2.134 ENSMUST00000075301.3
 Neb
nebulin
chr4_-_14621805 2.129 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr1_-_14310198 2.128 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr15_-_102722150 2.121 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 8.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 5.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.8 5.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.5 5.4 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.2 4.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 4.5 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.3 3.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 3.3 GO:0015807 L-amino acid transport(GO:0015807)
0.6 3.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.4 2.9 GO:0019532 oxalate transport(GO:0019532)
0.0 2.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 2.3 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.0 2.2 GO:0008360 regulation of cell shape(GO:0008360)
0.4 2.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 2.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 2.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 1.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 1.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 1.6 GO:0006883 cellular sodium ion homeostasis(GO:0006883)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0000785 chromatin(GO:0000785)
0.0 7.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.8 5.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.5 4.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 3.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.1 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.6 GO:0009925 basal plasma membrane(GO:0009925)
0.4 1.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.3 GO:0072562 blood microparticle(GO:0072562)
0.2 1.2 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.0 1.0 GO:0045177 apical part of cell(GO:0045177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 9.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 9.4 GO:0008083 growth factor activity(GO:0008083)
0.1 7.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 4.7 GO:0071889 14-3-3 protein binding(GO:0071889)
1.1 4.6 GO:0050436 microfibril binding(GO:0050436)
0.0 4.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 4.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 4.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 3.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 2.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 2.9 GO:0044325 ion channel binding(GO:0044325)
0.0 2.8 GO:0017124 SH3 domain binding(GO:0017124)
0.6 2.3 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.1 2.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.4 1.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 1.6 GO:1990715 mRNA CDS binding(GO:1990715)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 7.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 5.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 5.4 PID_EPO_PATHWAY EPO signaling pathway
0.1 4.5 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.6 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 2.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 1.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 1.4 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.9 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 0.8 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 0.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 5.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 4.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 3.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 3.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 2.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 1.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.2 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 0.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling