Motif ID: Runx2_Bcl11a

Z-value: 1.148

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24078022_240780760.105.2e-01Click!


Activity profile for motif Runx2_Bcl11a.

activity profile for motif Runx2_Bcl11a


Sorted Z-values histogram for motif Runx2_Bcl11a

Sorted Z-values for motif Runx2_Bcl11a



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 9.955 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr8_-_11008458 8.102 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr4_+_144892813 6.558 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_+_58210397 5.603 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chrX_+_159697308 5.545 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr15_-_66801577 4.387 ENSMUST00000168589.1
 Sla
src-like adaptor
chr11_+_3330781 4.362 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr4_+_144893127 3.962 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr9_-_103219823 3.959 ENSMUST00000168142.1
 Trf
transferrin
chr10_+_61171954 3.775 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr16_+_42907563 3.764 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr5_-_77408034 3.659 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chr4_+_48049080 3.612 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr11_+_101246960 3.324 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr11_+_80183851 3.192 ENSMUST00000017839.2
 Rnf135
ring finger protein 135
chr11_-_116654245 3.115 ENSMUST00000021166.5
 Cygb
cytoglobin
chr11_-_106388066 3.099 ENSMUST00000106813.2
ENSMUST00000141146.1
 Icam2

intercellular adhesion molecule 2

chr17_+_88626549 3.091 ENSMUST00000163588.1
ENSMUST00000064035.6
 Ston1

stonin 1

chr1_+_169655493 2.846 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr17_+_75178797 2.845 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 281 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.0 GO:0042572 retinol metabolic process(GO:0042572)
0.9 7.7 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
1.0 7.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 7.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.9 5.6 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 5.2 GO:0006897 endocytosis(GO:0006897)
0.2 5.1 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.6 4.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 4.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 4.3 GO:0015807 L-amino acid transport(GO:0015807)
0.0 4.2 GO:0007416 synapse assembly(GO:0007416)
0.5 4.0 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.6 3.9 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 3.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
1.2 3.6 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.6 3.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.6 3.1 GO:0015671 oxygen transport(GO:0015671)
1.0 3.0 GO:0050975 sensory perception of touch(GO:0050975)
0.2 3.0 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.9 2.7 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 10.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 5.5 GO:0072562 blood microparticle(GO:0072562)
0.0 5.4 GO:0030139 endocytic vesicle(GO:0030139)
1.7 5.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 4.3 GO:0043204 perikaryon(GO:0043204)
0.5 4.0 GO:0097433 dense body(GO:0097433)
0.0 4.0 GO:0001650 fibrillar center(GO:0001650)
0.0 3.7 GO:0055037 recycling endosome(GO:0055037)
0.0 3.5 GO:0005901 caveola(GO:0005901)
0.7 3.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 3.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 3.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 3.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 2.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.4 GO:0045177 apical part of cell(GO:0045177)
0.3 2.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 2.1 GO:0042629 mast cell granule(GO:0042629)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.3 1.7 GO:1990246 uniplex complex(GO:1990246)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 11.7 GO:0005158 insulin receptor binding(GO:0005158)
2.5 10.0 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
2.4 7.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 6.8 GO:0017124 SH3 domain binding(GO:0017124)
1.4 5.6 GO:0030151 molybdenum ion binding(GO:0030151)
1.2 5.0 GO:0050436 microfibril binding(GO:0050436)
0.2 4.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 4.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 4.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 4.0 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 3.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.8 3.3 GO:0001851 complement component C3b binding(GO:0001851)
0.7 3.3 GO:0097643 amylin receptor activity(GO:0097643)
0.1 3.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.2 3.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.0 3.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 3.0 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 2.9 GO:0050840 extracellular matrix binding(GO:0050840)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 7.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 7.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 7.3 PID_EPO_PATHWAY EPO signaling pathway
0.1 6.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 6.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 5.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 3.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 3.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.7 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 2.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 2.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 2.3 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 2.2 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 2.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.0 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.2 5.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 4.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 4.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 4.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.4 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.7 3.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 3.3 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.5 3.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 2.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.5 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 2.4 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling