Motif ID: Rxrb

Z-value: 0.696


Transcription factors associated with Rxrb:

Gene SymbolEntrez IDGene Name
Rxrb ENSMUSG00000039656.10 Rxrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrbmm10_v2_chr17_+_34032071_34032196-0.231.4e-01Click!


Activity profile for motif Rxrb.

activity profile for motif Rxrb


Sorted Z-values histogram for motif Rxrb

Sorted Z-values for motif Rxrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Rxrb

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_118052235 6.144 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr10_+_93641041 4.197 ENSMUST00000020204.4
 Ntn4
netrin 4
chr18_+_57142782 3.887 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr4_+_136143497 3.602 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr4_-_117178726 3.380 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr6_-_23248264 3.330 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_-_88146867 2.817 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr1_+_84839833 2.663 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr1_+_146420434 2.656 ENSMUST00000163646.1
 Gm5263
predicted gene 5263
chr12_+_91400990 2.486 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr4_+_44300876 2.442 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr11_+_40733936 2.349 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chr5_+_110839973 2.236 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr11_-_40733373 2.194 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr11_+_40733639 2.035 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr1_+_6487231 1.972 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr1_-_170306332 1.761 ENSMUST00000179801.1
 Gm7694
predicted gene 7694
chr5_-_116422858 1.702 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr1_+_74791516 1.677 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr10_+_88147061 1.659 ENSMUST00000169309.1
 Nup37
nucleoporin 37

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.8 4.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.6 3.9 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.1 3.6 GO:0030903 notochord development(GO:0030903)
0.7 3.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.6 3.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 3.3 GO:0051028 mRNA transport(GO:0051028)
0.2 2.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.4 2.5 GO:1904587 response to glycoprotein(GO:1904587)
0.1 2.4 GO:0000338 protein deneddylation(GO:0000338)
0.0 2.4 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.6 2.2 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.2 2.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 1.9 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.0 1.8 GO:0006457 protein folding(GO:0006457)
0.2 1.7 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.2 1.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 1.7 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.5 1.4 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 1.4 GO:0070208 protein heterotrimerization(GO:0070208)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 4.4 GO:0000776 kinetochore(GO:0000776)
0.1 4.3 GO:0035371 microtubule plus-end(GO:0035371)
0.2 3.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.9 GO:0005604 basement membrane(GO:0005604)
0.0 3.6 GO:0043235 receptor complex(GO:0043235)
0.3 3.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.0 2.7 GO:0016605 PML body(GO:0016605)
0.0 2.7 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.9 GO:0016234 inclusion body(GO:0016234)
0.0 1.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 1.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.3 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.1 GO:0014704 intercalated disc(GO:0014704)
0.3 1.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 1.0 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 4.8 GO:0043237 laminin-1 binding(GO:0043237)
0.6 3.9 GO:0001849 complement component C1q binding(GO:0001849)
0.0 3.8 GO:0051082 unfolded protein binding(GO:0051082)
0.2 3.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 3.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 3.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 2.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.7 GO:0005109 frizzled binding(GO:0005109)
0.0 1.7 GO:0005178 integrin binding(GO:0005178)
0.0 1.6 GO:0051087 chaperone binding(GO:0051087)
0.0 1.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 1.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 1.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 1.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.0 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.5 PID_ATM_PATHWAY ATM pathway
0.1 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.1 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.4 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.8 2.5 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 2.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 2.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 2.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 1.8 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)