Motif ID: Scrt2

Z-value: 1.395


Transcription factors associated with Scrt2:

Gene SymbolEntrez IDGene Name
Scrt2 ENSMUSG00000060257.2 Scrt2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Scrt2mm10_v2_chr2_+_152081529_152081624-0.742.6e-08Click!


Activity profile for motif Scrt2.

activity profile for motif Scrt2


Sorted Z-values histogram for motif Scrt2

Sorted Z-values for motif Scrt2



Network of associatons between targets according to the STRING database.



First level regulatory network of Scrt2

PNG image of the network

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Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_34649987 16.308 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr7_-_25250720 12.607 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr10_+_56377300 11.606 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr15_-_98004634 11.600 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr11_-_55419898 11.177 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr2_+_31950257 10.643 ENSMUST00000001920.7
 Aif1l
allograft inflammatory factor 1-like
chr7_-_30973399 10.519 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr17_-_25570678 10.095 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr2_-_164443177 9.960 ENSMUST00000017153.3
 Sdc4
syndecan 4
chr7_-_30973367 9.809 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973464 9.386 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr2_+_91257323 7.483 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr1_-_133424377 7.261 ENSMUST00000153799.1
 Sox13
SRY-box containing gene 13
chr2_+_91256813 7.005 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
 Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr3_-_108840477 6.438 ENSMUST00000106596.3
ENSMUST00000102621.4
 Stxbp3a

syntaxin binding protein 3A

chr6_-_53820764 5.510 ENSMUST00000127748.2
 Tril
TLR4 interactor with leucine-rich repeats
chrX_-_72274747 5.458 ENSMUST00000064780.3
 Gabre
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr7_+_126847908 5.315 ENSMUST00000147257.1
ENSMUST00000139174.1
 Doc2a

double C2, alpha

chr6_-_135168162 5.271 ENSMUST00000045855.7
 Hebp1
heme binding protein 1
chr6_-_23839137 5.163 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2








Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.9 29.7 GO:1904274 tricellular tight junction assembly(GO:1904274)
2.3 16.3 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.6 14.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
2.5 12.6 GO:0010668 ectodermal cell differentiation(GO:0010668)
3.9 11.6 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
1.1 11.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.3 11.2 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.9 10.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
3.4 10.1 GO:0072034 renal vesicle induction(GO:0072034)
2.0 10.0 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.6 7.3 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.2 6.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 5.5 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.2 5.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7 5.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.3 5.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 5.0 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
1.6 4.8 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.2 4.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 4.4 GO:0042168 heme metabolic process(GO:0042168)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.0 29.7 GO:0061689 tricellular tight junction(GO:0061689)
0.1 23.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 16.1 GO:0070382 exocytic vesicle(GO:0070382)
0.3 13.7 GO:0043034 costamere(GO:0043034)
1.1 11.6 GO:0005916 fascia adherens(GO:0005916)
1.0 11.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 11.6 GO:0005802 trans-Golgi network(GO:0005802)
2.8 11.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 8.4 GO:0016607 nuclear speck(GO:0016607)
0.0 6.3 GO:0005884 actin filament(GO:0005884)
0.9 5.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 5.5 GO:0005814 centriole(GO:0005814)
0.2 5.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 4.4 GO:0005604 basement membrane(GO:0005604)
0.0 4.4 GO:0005667 transcription factor complex(GO:0005667)
0.8 3.9 GO:0033010 paranodal junction(GO:0033010)
0.4 3.9 GO:0030057 desmosome(GO:0030057)
0.2 3.7 GO:0042555 MCM complex(GO:0042555)
0.4 3.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 3.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 29.7 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.8 16.1 GO:0035198 miRNA binding(GO:0035198)
1.1 14.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 13.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 12.6 GO:0003714 transcription corepressor activity(GO:0003714)
2.9 11.6 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
2.3 11.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 11.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 10.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 10.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
2.0 10.0 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 9.7 GO:0051015 actin filament binding(GO:0051015)
0.1 9.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 6.0 GO:0003924 GTPase activity(GO:0003924)
0.4 5.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.3 5.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 5.3 GO:0020037 heme binding(GO:0020037)
1.3 5.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 4.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 4.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.2 NABA_COLLAGENS Genes encoding collagen proteins
0.3 11.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 11.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 10.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 10.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 4.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 3.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 3.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 3.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.0 11.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
1.0 10.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.4 10.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 9.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 4.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 3.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 3.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 3.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 1.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism