Motif ID: Sin3a

Z-value: 1.323


Transcription factors associated with Sin3a:

Gene SymbolEntrez IDGene Name
Sin3a ENSMUSG00000042557.8 Sin3a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sin3amm10_v2_chr9_+_57072024_570720480.381.5e-02Click!


Activity profile for motif Sin3a.

activity profile for motif Sin3a


Sorted Z-values histogram for motif Sin3a

Sorted Z-values for motif Sin3a



Network of associatons between targets according to the STRING database.



First level regulatory network of Sin3a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_69360294 9.525 ENSMUST00000033532.6
 Aff2
AF4/FMR2 family, member 2
chr18_+_64340225 7.335 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chrX_-_104201126 5.320 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr1_-_119837613 4.998 ENSMUST00000064091.5
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chrX_-_104201099 4.945 ENSMUST00000087879.4
 C77370
expressed sequence C77370
chr15_-_66286224 4.872 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr4_+_107802277 4.811 ENSMUST00000106733.2
ENSMUST00000030356.3
ENSMUST00000106732.2
ENSMUST00000126573.1
 Lrp8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr18_-_72351009 4.452 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma
chr7_+_57591147 4.362 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr12_-_64965496 4.361 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr2_+_145167706 4.305 ENSMUST00000110007.1
 Slc24a3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr18_-_72351029 4.259 ENSMUST00000114943.3
 Dcc
deleted in colorectal carcinoma
chr9_-_40455670 4.162 ENSMUST00000165104.1
ENSMUST00000045682.5
 Gramd1b

GRAM domain containing 1B

chr14_-_103346765 4.046 ENSMUST00000159855.1
 Mycbp2
MYC binding protein 2
chr6_-_39206782 3.856 ENSMUST00000002305.8
 Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr10_-_43174521 3.691 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr1_-_119837338 3.667 ENSMUST00000163435.1
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr1_-_135585314 3.660 ENSMUST00000040599.8
ENSMUST00000067414.6
 Nav1

neuron navigator 1

chr1_-_119836999 3.658 ENSMUST00000163621.1
ENSMUST00000168303.1
 Ptpn4

protein tyrosine phosphatase, non-receptor type 4

chr4_-_22488296 3.643 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 565 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 14.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 12.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.9 9.5 GO:0035063 nuclear speck organization(GO:0035063)
0.1 9.1 GO:0006813 potassium ion transport(GO:0006813)
1.4 8.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.5 7.4 GO:1990403 embryonic brain development(GO:1990403)
0.7 7.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.7 6.3 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.4 6.2 GO:0060081 membrane hyperpolarization(GO:0060081)
2.0 6.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.7 5.7 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.6 5.7 GO:0071420 cellular response to histamine(GO:0071420)
0.4 5.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 5.6 GO:0007605 sensory perception of sound(GO:0007605)
0.9 5.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.3 5.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 5.0 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.5 5.0 GO:0042118 endothelial cell activation(GO:0042118)
1.6 4.9 GO:1904978 regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
1.2 4.8 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 219 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.8 GO:0014069 postsynaptic density(GO:0014069)
0.5 16.6 GO:0043194 axon initial segment(GO:0043194)
0.4 15.2 GO:0032809 neuronal cell body membrane(GO:0032809)
2.5 14.7 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 13.6 GO:0005814 centriole(GO:0005814)
0.1 10.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.8 9.0 GO:0032584 growth cone membrane(GO:0032584)
0.5 7.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 7.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 7.2 GO:0005802 trans-Golgi network(GO:0005802)
0.2 6.8 GO:0060170 ciliary membrane(GO:0060170)
0.2 6.7 GO:0030673 axolemma(GO:0030673)
0.6 5.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 5.6 GO:0016605 PML body(GO:0016605)
0.9 5.4 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.3 5.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.5 4.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 4.8 GO:0010369 chromocenter(GO:0010369)
0.2 4.7 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 4.6 GO:0030132 clathrin coat of coated pit(GO:0030132)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 317 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 14.6 GO:0008017 microtubule binding(GO:0008017)
1.3 14.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
1.7 12.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 10.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.5 8.9 GO:0005042 netrin receptor activity(GO:0005042)
0.1 8.4 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.5 8.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 7.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 7.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 7.4 GO:0030507 spectrin binding(GO:0030507)
0.8 7.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.9 7.1 GO:0046790 virion binding(GO:0046790)
1.0 6.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.8 6.1 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
1.0 6.0 GO:0045322 unmethylated CpG binding(GO:0045322)
0.5 5.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 5.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.3 5.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 5.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 8.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 7.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.4 7.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 7.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.4 6.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 6.6 PID_BCR_5PATHWAY BCR signaling pathway
0.2 5.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 5.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 5.1 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 4.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 4.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 3.6 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.1 3.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 2.8 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 2.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 2.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 2.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.4 2.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 10.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.7 9.4 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 9.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.5 8.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 7.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 6.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 5.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 5.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 5.7 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.2 5.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 5.5 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.2 5.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 5.1 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 4.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 4.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 4.5 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.5 4.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 4.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.4 4.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors