Motif ID: Six4

Z-value: 0.633


Transcription factors associated with Six4:

Gene SymbolEntrez IDGene Name
Six4 ENSMUSG00000034460.8 Six4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.076.5e-01Click!


Activity profile for motif Six4.

activity profile for motif Six4


Sorted Z-values histogram for motif Six4

Sorted Z-values for motif Six4



Network of associatons between targets according to the STRING database.



First level regulatory network of Six4

PNG image of the network

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Top targets:


Showing 1 to 20 of 59 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.561 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr6_+_7555053 2.885 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr7_-_137314394 2.742 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr17_+_35049966 2.388 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr7_-_143460989 2.309 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr13_+_54071815 2.255 ENSMUST00000021930.8
 Sfxn1
sideroflexin 1
chr13_+_51645232 2.157 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr14_-_103843685 2.019 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr7_+_29307924 1.961 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr8_+_62951361 1.950 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr7_+_29309429 1.848 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr6_+_50110186 1.609 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
 Mpp6


membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)


chr1_-_78968079 1.606 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr11_+_67078293 1.533 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
 Myh3


myosin, heavy polypeptide 3, skeletal muscle, embryonic


chr3_+_40950631 1.455 ENSMUST00000048490.6
 Larp1b
La ribonucleoprotein domain family, member 1B
chr5_-_145191511 1.403 ENSMUST00000161845.1
 Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr13_-_9878998 1.364 ENSMUST00000063093.9
 Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr4_-_134018829 1.226 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr8_-_84237042 1.171 ENSMUST00000039480.5
 Zswim4
zinc finger SWIM-type containing 4
chr6_+_134929118 1.145 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 7.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 2.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 2.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.3 2.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 2.3 GO:0006826 iron ion transport(GO:0006826)
0.0 2.2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.7 2.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.2 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.3 1.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 1.4 GO:0006754 ATP biosynthetic process(GO:0006754)
0.1 1.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 1.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.2 0.9 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 0.8 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.8 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.2 0.7 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.7 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.7 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.6 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 GO:0071565 nBAF complex(GO:0071565)
0.1 2.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 1.5 GO:0032982 myosin filament(GO:0032982)
0.1 1.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 0.8 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.7 GO:0005638 lamin filament(GO:0005638)
0.1 0.7 GO:0001740 Barr body(GO:0001740)
0.0 0.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 2.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.4 GO:0005254 chloride channel activity(GO:0005254)
0.2 2.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.5 2.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.7 2.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.2 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.5 GO:0000146 microfilament motor activity(GO:0000146)
0.3 1.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.4 GO:0016887 ATPase activity(GO:0016887)
0.1 1.2 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 1.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.0 GO:0019213 deacetylase activity(GO:0019213)
0.2 0.9 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.8 GO:0001847 opsonin receptor activity(GO:0001847)
0.1 0.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.8 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 1.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.3 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.7 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha