Motif ID: Six6

Z-value: 0.437


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_72939758-0.211.9e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Showing 1 to 20 of 158 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_140607334 2.479 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_+_78324200 2.398 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr9_+_98422961 1.873 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr6_-_23248264 1.806 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_98412461 1.767 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr14_+_67234620 1.395 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr4_-_97584605 1.225 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 1.167 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr8_-_94918012 1.011 ENSMUST00000077955.5
 Ccdc102a
coiled-coil domain containing 102A
chr1_+_45311538 0.902 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr4_-_43653542 0.891 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr7_+_46847128 0.881 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr4_+_156013835 0.853 ENSMUST00000030952.5
 Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
chrX_-_142966709 0.848 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr15_-_82244716 0.818 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr8_+_40423786 0.807 ENSMUST00000049389.4
ENSMUST00000128166.1
ENSMUST00000167766.1
 Zdhhc2


zinc finger, DHHC domain containing 2


chr4_-_43653560 0.804 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chr10_+_24595623 0.764 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr12_+_52097737 0.733 ENSMUST00000040090.9
 Nubpl
nucleotide binding protein-like
chr8_+_69832633 0.672 ENSMUST00000131637.2
ENSMUST00000081503.6
 Pbx4

pre B cell leukemia homeobox 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.5 GO:0007386 compartment pattern specification(GO:0007386)
0.2 2.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 1.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.6 1.8 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.3 1.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.5 GO:0007338 single fertilization(GO:0007338)
0.1 1.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 1.0 GO:0018345 protein palmitoylation(GO:0018345)
0.3 0.9 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.2 0.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 0.9 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 0.9 GO:0070236 positive regulation of immunoglobulin secretion(GO:0051024) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.8 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.7 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 0.6 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.6 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.2 0.5 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.2 0.5 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.5 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 0.5 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.8 GO:0043219 lateral loop(GO:0043219)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.1 0.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0001741 XY body(GO:0001741)
0.1 0.6 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0001772 immunological synapse(GO:0001772)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 2.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 1.9 GO:0019841 retinol binding(GO:0019841)
0.6 1.8 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 1.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.2 0.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.6 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 0.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.5 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.5 GO:0035198 miRNA binding(GO:0035198)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.8 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 1.0 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.1 0.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.9 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 0.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.2 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand