Motif ID: Snai1_Zeb1_Snai2

Z-value: 1.684

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.343.0e-02Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.182.7e-01Click!
Snai1mm10_v2_chr2_+_167538192_167538210-0.067.1e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_82616885 10.226 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr13_-_57907587 8.230 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr4_+_85205417 8.227 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr18_-_61911783 7.396 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr8_-_113848615 6.167 ENSMUST00000093113.4
 Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr15_-_66831625 6.061 ENSMUST00000164163.1
 Sla
src-like adaptor
chr1_-_134234492 5.817 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr16_+_18776839 5.458 ENSMUST00000043577.1
 Cldn5
claudin 5
chr4_+_85205120 4.983 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr5_-_147076482 4.724 ENSMUST00000016664.7
 Lnx2
ligand of numb-protein X 2
chr5_-_139130159 4.684 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr7_-_27446599 4.586 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr5_+_35056813 4.489 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr2_-_32312162 4.442 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr6_-_8778106 4.280 ENSMUST00000151758.1
ENSMUST00000115519.1
ENSMUST00000153390.1
 Ica1


islet cell autoantigen 1


chr7_+_44384803 4.248 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr5_+_35057059 4.223 ENSMUST00000050709.3
 Dok7
docking protein 7
chr15_+_83791939 4.167 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chrX_+_159627265 4.121 ENSMUST00000112456.2
 Sh3kbp1
SH3-domain kinase binding protein 1
chr14_-_49525840 4.051 ENSMUST00000138884.1
ENSMUST00000074368.4
ENSMUST00000123534.1
 Slc35f4


solute carrier family 35, member F4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 939 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.5 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.5 11.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 9.6 GO:0008654 phospholipid biosynthetic process(GO:0008654)
1.4 9.5 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.2 8.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
2.8 8.3 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
0.2 7.2 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.6 7.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.7 7.0 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.1 7.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 6.9 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.8 6.8 GO:0071420 cellular response to histamine(GO:0071420)
0.4 6.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 6.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 6.2 GO:0008333 endosome to lysosome transport(GO:0008333)
1.0 6.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.5 5.9 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.3 5.8 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.6 5.7 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.5 5.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 314 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 41.6 GO:0016021 integral component of membrane(GO:0016021)
0.1 25.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.6 20.7 GO:0030673 axolemma(GO:0030673)
0.2 19.6 GO:0043195 terminal bouton(GO:0043195)
0.5 17.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.5 15.7 GO:0033268 node of Ranvier(GO:0033268)
0.2 12.1 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 11.6 GO:0005769 early endosome(GO:0005769)
0.1 11.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 10.7 GO:0032587 ruffle membrane(GO:0032587)
0.1 10.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 7.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 7.8 GO:0031594 neuromuscular junction(GO:0031594)
0.2 7.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 7.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.6 7.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 7.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.5 7.3 GO:0043196 varicosity(GO:0043196)
1.2 6.9 GO:0008091 spectrin(GO:0008091)
0.2 6.9 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 504 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 17.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 15.9 GO:0030507 spectrin binding(GO:0030507)
0.1 13.2 GO:0005096 GTPase activator activity(GO:0005096)
0.2 12.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 11.5 GO:0005158 insulin receptor binding(GO:0005158)
0.1 11.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.9 10.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 10.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 9.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.3 9.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.8 8.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.2 8.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.3 7.8 GO:0030552 cAMP binding(GO:0030552)
0.2 7.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.2 7.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 6.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.1 6.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.6 6.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.5 6.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 6.0 GO:0048306 calcium-dependent protein binding(GO:0048306)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 30.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 11.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 10.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 10.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.3 9.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 7.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 6.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 6.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 5.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 5.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 5.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 5.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.8 PID_LKB1_PATHWAY LKB1 signaling events
0.2 4.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 4.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 4.1 PID_ARF_3PATHWAY Arf1 pathway
0.2 3.9 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 3.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 19.2 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.5 17.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 13.1 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.5 12.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.4 11.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 11.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 9.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 8.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 8.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 8.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 8.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.5 7.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.6 7.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 4.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 4.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 4.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 4.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.4 4.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.3 4.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 4.0 REACTOME_GLYCOLYSIS Genes involved in Glycolysis