Motif ID: Sox11

Z-value: 0.456


Transcription factors associated with Sox11:

Gene SymbolEntrez IDGene Name
Sox11 ENSMUSG00000063632.5 Sox11

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox11mm10_v2_chr12_-_27342696_273427260.571.2e-04Click!


Activity profile for motif Sox11.

activity profile for motif Sox11


Sorted Z-values histogram for motif Sox11

Sorted Z-values for motif Sox11



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox11

PNG image of the network

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Top targets:


Showing 1 to 20 of 76 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_16378231 2.081 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr5_+_14514918 1.483 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr8_-_34965631 1.218 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr6_-_23248264 0.947 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_-_99516537 0.871 ENSMUST00000064762.4
 Map1b
microtubule-associated protein 1B
chr6_-_60829826 0.865 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr11_+_69364010 0.808 ENSMUST00000166700.1
 Gm17305
predicted gene, 17305
chr9_+_89909775 0.778 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr5_-_131616599 0.648 ENSMUST00000161804.1
 Auts2
autism susceptibility candidate 2
chr16_+_8830093 0.609 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr17_+_43016536 0.609 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr2_-_79456750 0.609 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr7_+_70388305 0.608 ENSMUST00000080024.5
 B130024G19Rik
RIKEN cDNA B130024G19 gene
chrX_+_85574018 0.586 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
 Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr19_-_46969474 0.585 ENSMUST00000086961.7
 Nt5c2
5'-nucleotidase, cytosolic II
chr2_+_154548888 0.581 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr4_-_44072578 0.571 ENSMUST00000173383.1
 Gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr14_-_52213379 0.551 ENSMUST00000140603.1
 Chd8
chromodomain helicase DNA binding protein 8
chr11_+_24080664 0.516 ENSMUST00000118955.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr16_-_50330987 0.502 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0010842 retina layer formation(GO:0010842)
0.5 1.5 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.4 1.2 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.2 0.9 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.2 0.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.9 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0 0.8 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.2 0.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.2 0.6 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.2 0.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.6 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.6 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.6 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.1 0.5 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.1 0.4 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.4 GO:0033572 transferrin transport(GO:0033572)
0.0 0.3 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.2 GO:0070125 mitochondrial translational elongation(GO:0070125)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.5 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 1.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.9 GO:0043196 varicosity(GO:0043196)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.5 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0097361 CIA complex(GO:0097361)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0005522 profilin binding(GO:0005522)
0.1 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.9 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.6 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.6 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.3 GO:0032052 bile acid binding(GO:0032052)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.9 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 0.6 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 0.6 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones