Motif ID: Sox14

Z-value: 1.133


Transcription factors associated with Sox14:

Gene SymbolEntrez IDGene Name
Sox14 ENSMUSG00000053747.8 Sox14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox14mm10_v2_chr9_-_99876147_99876193-0.241.3e-01Click!


Activity profile for motif Sox14.

activity profile for motif Sox14


Sorted Z-values histogram for motif Sox14

Sorted Z-values for motif Sox14



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.476 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_-_14523178 5.555 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr11_+_67586675 4.660 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr11_+_67586520 4.647 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr12_+_109545390 3.883 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr10_-_6980376 3.477 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr1_-_12991109 3.416 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chrX_-_167209149 3.325 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr18_-_43393346 3.272 ENSMUST00000025379.7
 Dpysl3
dihydropyrimidinase-like 3
chr2_+_102706356 3.023 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr13_-_58113592 3.007 ENSMUST00000160860.1
 Klhl3
kelch-like 3
chr4_+_62965560 3.005 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr4_+_13751297 2.988 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_60197173 2.826 ENSMUST00000131670.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr12_+_31265279 2.735 ENSMUST00000002979.8
ENSMUST00000170495.1
 Lamb1

laminin B1

chr3_-_88458876 2.715 ENSMUST00000147200.1
ENSMUST00000169222.1
 Sema4a

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

chr3_+_55461758 2.709 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr15_-_95528228 2.607 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr12_+_109546333 2.598 ENSMUST00000166636.2
 Meg3
maternally expressed 3
chr14_-_104467984 2.587 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.6 GO:0008360 regulation of cell shape(GO:0008360)
0.3 9.3 GO:0008340 determination of adult lifespan(GO:0008340)
1.2 7.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 5.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 5.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
1.2 4.9 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 4.8 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.4 4.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 3.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
1.1 3.4 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.3 3.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 3.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 3.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.6 3.0 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.5 3.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.4 3.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 3.0 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.4 2.8 GO:0061092 involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2 2.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 2.7 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.0 GO:0005884 actin filament(GO:0005884)
0.0 6.4 GO:0014069 postsynaptic density(GO:0014069)
0.1 6.2 GO:0043204 perikaryon(GO:0043204)
1.2 4.9 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 3.9 GO:0030027 lamellipodium(GO:0030027)
0.1 3.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 3.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.2 GO:0008021 synaptic vesicle(GO:0008021)
0.1 3.0 GO:0030673 axolemma(GO:0030673)
0.0 3.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.0 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 2.7 GO:0043034 costamere(GO:0043034)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 2.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.9 GO:0031258 catenin complex(GO:0016342) lamellipodium membrane(GO:0031258)
0.0 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 1.7 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 8.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 7.7 GO:0051015 actin filament binding(GO:0051015)
0.0 6.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.6 4.9 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 3.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.2 3.8 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 3.8 GO:0001540 beta-amyloid binding(GO:0001540)
1.1 3.4 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.3 3.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.4 3.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 3.3 GO:0003785 actin monomer binding(GO:0003785)
0.5 3.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 2.9 GO:0005080 protein kinase C binding(GO:0005080)
0.1 2.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.5 2.3 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 2.3 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.6 4.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.6 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 4.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 3.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 1.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.5 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 4.9 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 3.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 3.6 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 3.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.0 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.7 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.6 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.5 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.3 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 0.9 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.9 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC