Motif ID: Sox18_Sox12

Z-value: 0.630

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox18mm10_v2_chr2_-_181671622_1816716450.057.6e-01Click!
Sox12mm10_v2_chr2_-_152398046_152398076-0.019.6e-01Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_113934679 2.641 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr14_+_62837679 2.029 ENSMUST00000014691.8
 Wdfy2
WD repeat and FYVE domain containing 2
chr8_-_67910911 1.606 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr16_-_91618986 1.512 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr7_+_24271568 1.510 ENSMUST00000032696.6
 Zfp93
zinc finger protein 93
chr5_+_14514918 1.451 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr1_+_55406163 1.387 ENSMUST00000042986.8
 Plcl1
phospholipase C-like 1
chr2_+_102706356 1.321 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr13_-_25020289 1.164 ENSMUST00000021772.2
 Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr16_-_23520579 1.160 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr2_-_59948155 1.153 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr11_-_62392605 1.144 ENSMUST00000151498.2
ENSMUST00000159069.1
 Ncor1

nuclear receptor co-repressor 1

chr14_+_116925379 1.034 ENSMUST00000088483.3
 Gpc6
glypican 6
chr18_+_69593361 1.033 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr1_-_169747634 1.026 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr14_-_100149764 0.997 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr1_-_176807124 0.988 ENSMUST00000057037.7
 Cep170
centrosomal protein 170
chr19_-_34527396 0.980 ENSMUST00000049572.8
ENSMUST00000178114.1
 Lipa

lysosomal acid lipase A

chr2_+_102659213 0.963 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_-_22694061 0.920 ENSMUST00000131767.1
 Ikbkb
inhibitor of kappaB kinase beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.6 GO:0048840 otolith development(GO:0048840)
0.3 2.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 2.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.2 1.8 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 1.5 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.4 1.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.2 1.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.3 1.3 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 1.3 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 1.2 GO:0015693 magnesium ion transport(GO:0015693)
0.3 1.1 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.0 1.1 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.3 1.0 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
0.1 1.0 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 1.0 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 1.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2 0.9 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 2.3 GO:0030673 axolemma(GO:0030673)
0.7 2.0 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 1.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 1.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.4 1.5 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.4 1.5 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 1.5 GO:0017119 Golgi transport complex(GO:0017119)
0.3 1.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 1.3 GO:0016592 mediator complex(GO:0016592)
0.1 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.1 1.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.5 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.4 2.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 2.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.4 1.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 1.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.4 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 1.4 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 1.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 1.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 0.9 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.8 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.1 0.8 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 NABA_COLLAGENS Genes encoding collagen proteins
0.2 1.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.7 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.4 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 1.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.4 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 1.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 1.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)