Motif ID: Sox2

Z-value: 3.152


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_34650005-0.803.9e-10Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_143933089 19.557 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_64122256 14.691 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr10_+_80300997 13.630 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr14_+_61138445 13.295 ENSMUST00000089394.3
ENSMUST00000119509.1
 Sacs

sacsin

chr1_-_138842429 12.814 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr5_-_112228633 12.796 ENSMUST00000182699.1
ENSMUST00000182258.1
ENSMUST00000183036.1
 Miat


myocardial infarction associated transcript (non-protein coding)


chr10_-_29144194 11.842 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr1_+_66322102 11.520 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr10_+_26229707 10.843 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr10_+_29143996 10.759 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chrX_-_143933204 9.798 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr5_-_112228900 9.418 ENSMUST00000182509.1
 Miat
myocardial infarction associated transcript (non-protein coding)
chr10_-_122047293 9.226 ENSMUST00000020322.5
ENSMUST00000081688.6
 Srgap1

SLIT-ROBO Rho GTPase activating protein 1

chr2_+_68861564 9.159 ENSMUST00000176018.1
 Cers6
ceramide synthase 6
chr7_+_99466004 8.911 ENSMUST00000037359.2
 Klhl35
kelch-like 35
chr4_-_20778527 8.909 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr7_-_74013676 8.805 ENSMUST00000026896.4
 St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr4_+_116221590 8.760 ENSMUST00000147292.1
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr1_+_6734827 8.713 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr1_-_12991109 8.559 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 486 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 33.2 GO:0048813 dendrite morphogenesis(GO:0048813)
2.0 29.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
2.6 28.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.8 27.6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
1.8 26.9 GO:0046548 retinal rod cell development(GO:0046548)
0.7 25.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.6 23.2 GO:0006376 mRNA splice site selection(GO:0006376)
1.7 20.2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.0 19.8 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.2 17.2 GO:0000045 autophagosome assembly(GO:0000045)
0.4 16.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
3.2 16.0 GO:0046684 response to pyrethroid(GO:0046684)
3.2 15.9 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.2 15.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.7 15.7 GO:1900034 regulation of cellular response to heat(GO:1900034)
5.1 15.3 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.7 13.4 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
1.5 13.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.6 12.8 GO:0035262 gonad morphogenesis(GO:0035262)
1.6 12.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 205 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 46.7 GO:0016021 integral component of membrane(GO:0016021)
0.1 42.9 GO:0030424 axon(GO:0030424)
0.2 39.8 GO:0014069 postsynaptic density(GO:0014069)
1.4 28.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
3.1 27.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.0 23.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 23.3 GO:0045202 synapse(GO:0045202)
0.6 22.1 GO:0090544 BAF-type complex(GO:0090544)
0.4 20.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 18.5 GO:0005871 kinesin complex(GO:0005871)
0.2 17.6 GO:0001669 acrosomal vesicle(GO:0001669)
1.1 16.0 GO:0016342 catenin complex(GO:0016342)
1.1 16.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
2.0 15.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 15.7 GO:0005886 plasma membrane(GO:0005886)
0.3 14.8 GO:0002102 podosome(GO:0002102)
1.4 14.1 GO:0045298 tubulin complex(GO:0045298)
0.5 13.5 GO:0030673 axolemma(GO:0030673)
0.2 13.5 GO:0008021 synaptic vesicle(GO:0008021)
0.6 12.9 GO:0031430 M band(GO:0031430)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 298 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 85.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 72.9 GO:0008017 microtubule binding(GO:0008017)
0.8 45.3 GO:0030507 spectrin binding(GO:0030507)
3.9 31.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 30.9 GO:0005096 GTPase activator activity(GO:0005096)
0.4 26.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 25.0 GO:0008270 zinc ion binding(GO:0008270)
0.8 24.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.4 23.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 20.0 GO:0017022 myosin binding(GO:0017022)
2.8 19.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.4 19.2 GO:0051018 protein kinase A binding(GO:0051018)
0.7 17.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.7 16.0 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
2.2 15.7 GO:0099609 microtubule lateral binding(GO:0099609)
0.5 15.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
1.6 14.8 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 14.8 GO:0001784 phosphotyrosine binding(GO:0001784)
1.6 14.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
3.1 12.5 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 48.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.6 46.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.6 25.3 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.4 24.5 PID_LKB1_PATHWAY LKB1 signaling events
0.4 20.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 16.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.5 15.8 PID_IL3_PATHWAY IL3-mediated signaling events
0.8 15.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 15.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.2 12.5 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 12.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 11.1 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 8.5 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.2 8.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 7.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 7.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 7.3 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.6 7.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 7.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 7.1 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 38.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.8 28.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 26.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
1.6 19.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.5 19.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.9 17.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.8 16.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.7 15.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 15.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 15.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.4 14.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 12.5 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.5 12.1 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.3 11.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.5 11.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4 10.3 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 10.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 10.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.4 9.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 9.2 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport