Motif ID: Sox21

Z-value: 0.548


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_118237035-0.409.0e-03Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_109993982 2.354 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr1_+_107511416 2.006 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr7_+_51621830 1.748 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chrM_+_14138 1.666 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr9_-_73968901 1.524 ENSMUST00000184666.1
 Unc13c
unc-13 homolog C (C. elegans)
chr18_-_34007206 1.486 ENSMUST00000025234.5
 Epb4.1l4a
erythrocyte protein band 4.1-like 4a
chr12_+_38783503 1.364 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr2_-_72986716 1.297 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chrM_-_14060 1.265 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr10_-_116972609 1.167 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr6_+_120666388 1.075 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr4_+_139923349 0.985 ENSMUST00000128563.1
 Gm13028
predicted gene 13028
chr3_-_33082004 0.957 ENSMUST00000108225.3
 Pex5l
peroxisomal biogenesis factor 5-like
chr1_+_62703667 0.906 ENSMUST00000114155.1
ENSMUST00000027112.6
ENSMUST00000063594.6
ENSMUST00000114157.2
 Nrp2



neuropilin 2



chr4_-_98383232 0.860 ENSMUST00000143116.1
ENSMUST00000030292.5
ENSMUST00000102793.4
 Tm2d1


TM2 domain containing 1


chr8_-_57652993 0.775 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr17_-_90088343 0.705 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr1_-_150465563 0.700 ENSMUST00000164600.1
ENSMUST00000111902.2
ENSMUST00000111901.2
ENSMUST00000006171.9
 Prg4



proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)



chr14_+_64588112 0.642 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr2_-_79908428 0.635 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.1 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.3 1.7 GO:0033762 response to glucagon(GO:0033762)
0.2 1.7 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 1.5 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 1.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.1 GO:0001842 neural fold formation(GO:0001842)
0.1 1.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 1.0 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.0 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.3 0.9 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.0 0.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.2 0.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.2 0.7 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 0.7 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.7 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.6 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.4 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0070469 respiratory chain(GO:0070469)
0.2 1.7 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 1.5 GO:0044305 calyx of Held(GO:0044305)
0.0 1.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 1.1 GO:0090537 CERF complex(GO:0090537)
0.2 1.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0016460 myosin II complex(GO:0016460)
0.1 0.2 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.5 1.5 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.2 1.1 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 1.0 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.3 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.3 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.1 REACTOME_MEIOSIS Genes involved in Meiosis