Motif ID: Sox3_Sox10

Z-value: 1.517

Transcription factors associated with Sox3_Sox10:

Gene SymbolEntrez IDGene Name
Sox10 ENSMUSG00000033006.9 Sox10
Sox3 ENSMUSG00000045179.8 Sox3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox3mm10_v2_chrX_-_60893430_60893440-0.517.5e-04Click!
Sox10mm10_v2_chr15_-_79164477_79164496-0.251.1e-01Click!


Activity profile for motif Sox3_Sox10.

activity profile for motif Sox3_Sox10


Sorted Z-values histogram for motif Sox3_Sox10

Sorted Z-values for motif Sox3_Sox10



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox3_Sox10

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_143933089 11.975 ENSMUST00000087313.3
 Dcx
doublecortin
chr11_+_67586520 10.649 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_67586675 10.639 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr1_+_66321708 8.354 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr1_+_66322102 8.022 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr10_-_29144194 7.315 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chrX_-_143933204 6.608 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr13_-_14523178 6.365 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr6_-_13839916 6.349 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr18_+_37484955 6.247 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr1_+_34579693 6.048 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr4_-_82705735 5.951 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr6_+_51432663 5.563 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr1_-_64122256 5.356 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr10_+_80300997 5.355 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr11_+_97415527 5.033 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr6_-_136171722 4.898 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr4_-_116405986 4.856 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr2_+_65845833 4.814 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr7_-_74013676 4.761 ENSMUST00000026896.4
 St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 399 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 25.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 18.8 GO:0030041 actin filament polymerization(GO:0030041)
1.3 18.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.7 15.2 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 13.1 GO:0007416 synapse assembly(GO:0007416)
0.2 10.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.2 9.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
1.0 9.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 8.9 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.6 8.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 8.3 GO:0050919 negative chemotaxis(GO:0050919)
2.7 8.0 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
1.6 7.9 GO:0046684 response to pyrethroid(GO:0046684)
0.5 7.8 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280)
0.2 7.7 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.2 7.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 7.2 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 7.2 GO:0000045 autophagosome assembly(GO:0000045)
0.9 6.9 GO:0086018 SA node cell action potential(GO:0086015) SA node cell to atrial cardiac muscle cell signalling(GO:0086018) SA node cell to atrial cardiac muscle cell communication(GO:0086070)
2.3 6.8 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 20.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
2.2 20.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 18.6 GO:0001726 ruffle(GO:0001726)
0.6 15.8 GO:0071565 nBAF complex(GO:0071565)
1.5 15.4 GO:0045298 tubulin complex(GO:0045298)
0.1 15.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 14.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 12.6 GO:0030427 site of polarized growth(GO:0030427)
0.8 12.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 11.5 GO:0031941 filamentous actin(GO:0031941)
0.1 11.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 10.8 GO:0043204 perikaryon(GO:0043204)
0.2 10.4 GO:0005871 kinesin complex(GO:0005871)
0.3 9.0 GO:0031430 M band(GO:0031430)
0.0 8.8 GO:0097708 cytoplasmic vesicle(GO:0031410) intracellular vesicle(GO:0097708)
0.3 7.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 7.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 7.0 GO:0030018 Z disc(GO:0030018)
2.3 6.9 GO:0002142 stereocilia ankle link complex(GO:0002142)
0.6 6.8 GO:0090544 BAF-type complex(GO:0090544)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 56.5 GO:0008017 microtubule binding(GO:0008017)
0.1 26.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
2.7 21.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 20.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 17.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.7 15.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
2.2 15.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 12.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 11.7 GO:0005096 GTPase activator activity(GO:0005096)
0.1 10.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 9.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 9.5 GO:0036002 pre-mRNA binding(GO:0036002)
1.0 9.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 8.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
1.0 8.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 8.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 8.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 8.2 GO:0001784 phosphotyrosine binding(GO:0001784)
2.7 8.0 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.7 7.6 GO:0031005 filamin binding(GO:0031005)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 17.4 PID_LKB1_PATHWAY LKB1 signaling events
0.8 15.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 11.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 10.3 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.3 9.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 9.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 9.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 8.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 7.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.6 PID_FOXO_PATHWAY FoxO family signaling
0.1 4.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 4.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.4 4.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 3.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 3.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 3.5 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.1 3.0 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 38.6 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.7 13.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.5 12.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.5 11.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 10.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 10.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 8.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 8.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 8.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.4 7.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.2 7.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 7.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 7.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.6 6.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.4 6.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 6.4 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.3 6.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.2 6.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.4 5.6 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.3 5.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation