Motif ID: Sox4

Z-value: 0.740


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_289537130.333.5e-02Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 121 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_3270767 3.830 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr2_-_33942111 3.509 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr8_-_84773381 3.049 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr17_+_75005523 2.931 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr13_-_97747399 2.727 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr14_+_101840602 2.702 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr18_-_62756275 2.509 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr13_-_97747373 2.280 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr7_+_99466004 2.279 ENSMUST00000037359.2
 Klhl35
kelch-like 35
chr14_+_101840501 2.073 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr1_+_165788681 1.877 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr1_+_165788746 1.612 ENSMUST00000161559.2
 Cd247
CD247 antigen
chr1_+_59482133 1.553 ENSMUST00000114246.2
ENSMUST00000037105.6
 Fzd7

frizzled homolog 7 (Drosophila)

chr5_-_122050102 1.548 ENSMUST00000154139.1
 Cux2
cut-like homeobox 2
chr10_-_17947997 1.413 ENSMUST00000037879.6
 Heca
headcase homolog (Drosophila)
chrX_-_10117597 1.391 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
 Srpx


sushi-repeat-containing protein


chr12_-_98577940 1.209 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr12_-_79296266 1.202 ENSMUST00000021547.6
 Zfyve26
zinc finger, FYVE domain containing 26
chr1_-_93101825 1.120 ENSMUST00000112958.2
 Kif1a
kinesin family member 1A
chrX_+_159840463 1.102 ENSMUST00000112451.1
ENSMUST00000112453.2
 Sh3kbp1

SH3-domain kinase binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0070207 protein homotrimerization(GO:0070207)
0.2 3.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 2.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 2.6 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 2.1 GO:0007416 synapse assembly(GO:0007416)
0.1 2.0 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 1.9 GO:0007614 short-term memory(GO:0007614)
0.2 1.8 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.4 1.6 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.4 1.6 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.5 1.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.4 1.3 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 1.1 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 1.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.9 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.9 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.8 GO:0046697 decidualization(GO:0046697)
0.1 0.7 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.9 3.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.0 2.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.0 1.3 GO:0030496 midbody(GO:0030496)
0.3 1.2 GO:0044307 dendritic branch(GO:0044307)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.1 0.7 GO:0097542 ciliary tip(GO:0097542)
0.0 0.7 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.6 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0042805 actinin binding(GO:0042805)
0.0 3.5 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.7 2.9 GO:0050436 microfibril binding(GO:0050436)
0.2 2.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.9 GO:0004697 protein kinase C activity(GO:0004697)
0.2 0.8 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.1 0.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.7 GO:0046790 virion binding(GO:0046790)
0.1 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.4 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 1.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 1.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions